Changing patient perceptions of the side effects of cancer chemotherapy.
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TLDR
The authors carried out a survey in 100 patients with cancer with the objectives of investigating the changes in patient perceptions that have occurred and evaluating the impact of new treatments on the profile of chemotherapy side effects among patients receiving anticancer drugs.Abstract:
BACKGROUND
Quality-of-life (QoL) issues have become increasingly important as the number of newly diagnosed patients with cancer increases and survival improves. In 1983, Coates et al. reported a survey of patient perceptions of the side effects of cancer chemotherapy and showed the importance of including patient feedback for the accurate assessment of QoL (Eur J Cancer Clin Oncol. 1983;19:203–208.). The authors carried out a similar survey in 100 patients with cancer with the objectives of 1) investigating the changes in patient perceptions that have occurred and 2) evaluating the impact of new treatments on the profile of chemotherapy side effects among patients receiving anticancer drugs.
METHODS
One hundred patients attending the outpatient Medical Oncology Department of the Pitie Salpetriere Hospital Group were surveyed between August 1998 and February 2000 by trained interviewers who were blinded to the patients' treatment. Patients identified all side effects associated with their treatment using a set of 45 cards that named physical side effects (Group A) and a set of 27 cards that named nonphysical side effects (Group B), and the patients ranked these side effects according to severity. The top 5 cards from each group were then combined, and the resulting 10 cards were rated again by severity, regardless of group. Results were analyzed for the entire cohort and for demographic, social, and clinical subgroups.
RESULTS
The participants included 65 women and 35 men; the most common malignancies were breast carcinoma (40 patients), gastrointestinal carcinoma (19 patients), lung carcinoma (7 patients), and ovarian carcinoma (9 patients). Patients rated affects my family or partner as the most severe side effect, alopecia was second, and fatigue was the third most severe. Effects on work or home responsibilities, effects on social activities, and loss of interest in sex were ranked fourth, fifth, and sixth, respectively. The results contrasted with those of Coates et al., in which affects my family or partner was ranked 10th, and fatigue was ranked 8th.
CONCLUSIONS
Patient perceptions of the side effects of cancer chemotherapy have changed markedly. In the current study, fatigue and psychosocial QoL concerns predominated, compared with emesis, nausea, and negative reactions to the treatment visit in the original survey. The current findings are consistent with the progress that has been made in reducing certain chemotherapy-associated toxicities. Fatigue, however, although it often is related to anemia and is treatable with recombinant human erythropoietin, remains a major concern. The emotional, social, and sexual consequences of cancer treatment present continuing challenges in efforts to optimize QoL and to develop effective supportive care. Cancer 2002;95:155–63. © 2002 American Cancer Society.
DOI 10.1002/cncr.10630read more
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References
More filters
Journal ArticleDOI
Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition
Gregory A. Curt,William Breitbart,David Cella,Jerome E. Groopman,Sandra J. Horning,Loretta M. Itri,David H. Johnson,Christine Miaskowski,Susan L. Scherr,Russell K. Portenoy,Nicholas J. Vogelzang +10 more
TL;DR: Cancer-related fatigue is common among cancer patients who have received chemotherapy and results in substantial adverse physical, psychosocial, and economic consequences for both patients and caregivers.
Journal ArticleDOI
Effects of Epoetin Alfa on Hematologic Parameters and Quality of Life in Cancer Patients Receiving Nonplatinum Chemotherapy: Results of a Randomized, Double-Blind, Placebo-Controlled Trial
TL;DR: Epoetin alfa safely and effectively ameliorates anemia and significantly improves QOL in cancer patients receiving nonplatinum chemotherapy in patients with solid or nonmyeloid hematologic malignancies.
Journal ArticleDOI
On the receiving end—patient perception of the side-effects of cancer chemotherapy
Alan S. Coates,Suzanne Abraham,S.B. Kaye,Timothy Sowerbutts,Cheryl Frewin,R. M. Fox,M. H. N. Tattersall +6 more
TL;DR: Differences in ranking of severity of side-effects were evident when patient groups were divided by sex, age, marital status and domestic situation, as well as by diagnosis, treatment and response.
Journal Article
Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. The Fatigue Coalition.
Vogelzang Nj,William Breitbart,David Cella,Curt Ga,Groopman Je,Horning Sj,Itri Lm,Johnson Dh,Scherr Sl,Portenoy Rk +9 more
TL;DR: For patients and oncologists, improving the quality of life of cancer patients requires a heightened awareness of fatigue, a better understanding of its impact, and improve communication and familiarity with interventions that can reduce its debilitating effects.
Journal ArticleDOI
Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: results from a prospective community oncology study. Procrit Study Group.
TL;DR: Epoetin alfa appears to have a beneficial impact on patient-reported functional capacity and quality of life in patients with cancer who received chemotherapy independent of tumor response.
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