Book ChapterDOI
CHAPTER 6 – Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity
Irwin Fridovich
- pp 239-277
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The article was published on 1976-01-01. It has received 429 citations till now. The article focuses on the topics: Hydrogen peroxide & Reactive oxygen species.read more
Citations
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Cell Damage in the Brain: A Speculative Synthesis
TL;DR: In this article, it was shown that the clinically most important conditions leading to brain cell death are those associated with cerebrovascul ar dise ase, particularly stroke, and with head trauma.
Journal ArticleDOI
Antioxidants/antimutagens in food.
TL;DR: Several reports have suggested that lipid peroxidation may result in destabilization and disintegration of cell membranes, leading to liver injury and other diseases, and finally, to aging and susceptibility to cancer.
Journal ArticleDOI
Oxygen metabolism and the toxic properties of phagocytes.
TL;DR: The products of oxygen reduction and excitation and enzymes that potentiate or limit the toxicity of these agents contribute to the complexity of the oxygen-dependent antimicrobial systems of phagocytes.
Journal ArticleDOI
The antioxidant role of vitamin C
TL;DR: Evidence is presented which supports the importance of vitamin C as a component of the overall antioxidant protective mechanisms found in cells and tissues and the protection by vitamin C of phagocytic cells involved in the defense against pathogen invasion.
Journal ArticleDOI
Quantitative measurement of the total, peroxyl radical-trapping antioxidant capability of human blood plasma by controlled peroxidation. The important contribution made by plasma proteins.
TL;DR: Evidence is presented to show that this previously unrecognized large reserve of antioxidant capacity is attributable to the plasma proteins.
References
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Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels☆
TL;DR: The staining procedure for localizing superoxide dismutase on polyacrylamide electrophoretograms has been applied to extracts obtained from a variety of sources and could thus be assayed either in crude extracts or in purified protein fractions.
Journal ArticleDOI
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
Journal ArticleDOI
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
Journal ArticleDOI
The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen
TL;DR: The reduction of nitro blue tetrazolium (NitroBT) with NADH mediated by phenazine methosulfate (PMS) under aerobic conditions was inhibited upon addition ofsuperoxide dismutase, indicating the involvement of superoxide aninon radical in the reduction of NitroBT.
Related Papers (5)
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more