Journal ArticleDOI
Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids
Tetsuo Yamagata,Mariko Morishita,Nikhil J. Kavimandan,Koji Nakamura,Yu Fukuoka,Kozo Takayama,Nicholas A. Peppas +6 more
TLDR
The results suggested that the insulin protection ability of the hydrogels contributed to improve oral insulin absorption and that P(MAA-g-EG) hydrogel can be an excellent carrier for protecting insulin during their transit through the GI tract.About:
This article is published in Journal of Controlled Release.The article was published on 2006-05-30. It has received 86 citations till now. The article focuses on the topics: Self-healing hydrogels & Insulin.read more
Citations
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Journal ArticleDOI
PEG hydrogels for the controlled release of biomolecules in regenerative medicine.
TL;DR: The design criteria that are important in maintaining the availability and stability of the biomolecules as well as the mechanisms for loading of biomolecule within PEG hydrogels will also be discussed.
Journal ArticleDOI
Stimuli-Responsive Polymeric Systems for Biomedical Applications
TL;DR: The general aspects of the different types of stimuli that can be used to modulate the response are reviewed mainly for the case of hydrogels and surfaces, based on natural‐origin or biodegradable macromolecules.
Journal ArticleDOI
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals.
TL;DR: The present work concisely reviews different administration routes as well as the advantages and disadvantages of each method, highlighting why oral delivery is currently the most promising approach.
Journal ArticleDOI
Current challenges in non-invasive insulin delivery systems: a comparative review.
TL;DR: This article concentrates on the successes in this new millennium in developing potential non-invasive technologies and devices, and on major new milestones in modern insulin delivery for the effective treatment of diabetes.
Journal ArticleDOI
Polymeric gels and hydrogels for biomedical and pharmaceutical applications
TL;DR: The preparation and applications of the molecularly imprinted polymeric hydrogels (MIPs) are illustrated by a few examples and the use of shape sensitive hydrogel in microfluidic is mentioned.
References
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Journal ArticleDOI
Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal ArticleDOI
Oral delivery of insulin using pH‐responsive complexation gels
TL;DR: P pH-responsive, poly(methacrylic-g-ethylene glycol) hydrogels are investigated as oral delivery vehicles for insulin to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine.
Journal ArticleDOI
The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins
TL;DR: Initial steps in this direction can be seen in the development of delivery system containing mucoadhesive polymers providing an intimate contact to the mucosa, thereby reducing the drug degradation between delivery system and absorbing membrane, controlled release systems which provide a simultaneous release of drug and inhibitor and in the immobilisation of enzyme inhibitors on delivery systems.
Journal ArticleDOI
Effects of Various Protease Inhibitors on the Intestinal Absorption and Degradation of Insulin in Rats
Akira Yamamoto,Toshio Taniguchi,Kaori Rikyuu,Tomoko Tsuji,Takuya Fujita,Masahiro Murakami,Shozo Muranishi +6 more
TL;DR: It was found that the reduction in the proteolytic rate of insulin was related to the decrease in plasma glucose concentration by these protease inhibitors in the large intestine.
Journal Article
Enzymatic barriers for GI peptide and protein delivery
TL;DR: From a knowledge of the enzymatic barrier, the strategies for oral peptide delivery of enzyme inhibition and the synthesis of enzyme-resistant peptide analogues are logical developments.