Journal ArticleDOI
Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
Koji Nakamura,Robert J. Murray,Jeffrey I. Joseph,Nicholas A. Peppas,Mariko Morishita,Anthony M. Lowman +5 more
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TLDR
All of the insulin loaded formulations produced significant insulin absorption in the upper small intestine combined with hypoglycemic effects, and all of the hydrogels were able to incorporate insulin and protected it from release in acidic media.About:
This article is published in Journal of Controlled Release.The article was published on 2004-03-24. It has received 184 citations till now. The article focuses on the topics: Self-healing hydrogels & Insulin.read more
Citations
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PEG hydrogels for the controlled release of biomolecules in regenerative medicine.
TL;DR: The design criteria that are important in maintaining the availability and stability of the biomolecules as well as the mechanisms for loading of biomolecule within PEG hydrogels will also be discussed.
Journal ArticleDOI
Stimulus-responsive hydrogels: Theory, modern advances, and applications
TL;DR: This extensive review identifies and discusses the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels.
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Smart polymeric gels : Redefining the limits of biomedical devices
TL;DR: The barriers in the current performance potential of biomedical devices can be lowered or removed by the rapid convergence of interdisciplinary technologies, involving supramolecular chemistry.
Journal ArticleDOI
Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels.
TL;DR: P(AA-g-EG) hydrogels can be successfully used as drug delivery systems because their versatility to be designed with specifically tuned release properties renders these biomaterials promising pharmaceutical carriers for therapeutic agents.
Journal ArticleDOI
Current challenges in non-invasive insulin delivery systems: a comparative review.
TL;DR: This article concentrates on the successes in this new millennium in developing potential non-invasive technologies and devices, and on major new milestones in modern insulin delivery for the effective treatment of diabetes.
References
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Book
The physics of rubber elasticity
TL;DR: In this paper, the Elasticity of Long-Chain Molecules (LCHs) and Elasticity in a Molecular Network (MNNs) is investigated. But the authors focus on the elasticity of the long chain Molecules.
Book
Principles of polymer chemistry
TL;DR: In this paper, Free-Radical Chain-Growth Polymerization (FRCG) and Ionic chain-growth polymers (Ionic chain growth polymers) are discussed.
Journal ArticleDOI
Nanoparticle uptake by the rat gastrointestinal mucosa : quantitation and particle size dependency
TL;DR: Measurement of radioactivity of tissues following administration of 100 nm and 1 μm I125‐labelled polystyrene latex particles for 8 days was corroborative although less secure because of the potential lability of the labelled particles.
Journal ArticleDOI
Oral delivery of insulin using pH‐responsive complexation gels
TL;DR: P pH-responsive, poly(methacrylic-g-ethylene glycol) hydrogels are investigated as oral delivery vehicles for insulin to protect the sensitive drug from proteolytic degradation in the stomach and upper portion of the small intestine.