Journal ArticleDOI
Chemical characterization of silicon-substituted hydroxyapatite.
TLDR
Chemical analysis confirmed the proposed substitution of the silicon (or silicate) ion for the phosphorus (or phosphate) ion in hydroxyapatite and demonstrated that phase-pure silicon-substituted hydroxyAPatite may be prepared using a simple precipitation technique.Abstract:
Bioceramic specimens have been prepared by incorporating a small amount of silicon (0.4 wt %) into the structure of hydroxyapatite [Ca10(PO4)6(OH)2, HA] via an aqueous precipitation reaction to produce a silicon-substituted hydroxyapatite (Si-HA). The results of chemical analysis confirmed the proposed substitution of the silicon (or silicate) ion for the phosphorus (or phosphate) ion in hydroxyapatite. The Si-HA was produced by first preparing a silicon-substituted apatite (Si-Ap) by a precipitation process. A single-phase Si-HA was obtained by heating/calcining the as-prepared Si-Ap to temperatures above 700 degrees C; no secondary phases, such as tricalcium phosphate (TCP), tetracalcium phosphate (TeCP), or calcium oxide (CaO), were observed by X-ray diffraction analysis. Although the X-ray diffraction patterns of Si-HA and stoichiometric HA appeared to be identical, refinement of the diffraction data revealed some small structural differences between the two materials. The silicon substitution in the HA lattice resulted in a small decrease in the a axis and an increase in the c axis of the unit cell. This substitution also caused a decrease in the number of hydroxyl (OH) groups in the unit cell, which was expected from the proposed substitution mechanism. The incorporation of silicon in the HA lattice resulted in an increase in the distortion of the PO4 tetrahedra, indicated by an increase in the distortion index. Analysis of the Si-HA by Fourier transform infrared (FTIR) spectroscopy indicated that although the amount of silicon incorporated into the HA lattice was small, silicon substitution appeared to affect the FTIR spectra of HA, in particular the P-O vibrational bands. The results demonstrate that phase-pure silicon-substituted hydroxyapatite may be prepared using a simple precipitation technique.read more
Citations
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Journal ArticleDOI
Collagen/silicocarnotite composites, cross-linked with chondroitin sulphate: In vitro bioactivity
Lachezar Radev,Vladimir Hristov,Irena Michailova,Maria Helena Fernandes,Isabel M. Miranda Salvado +4 more
TL;DR: In this paper, the experimental results on synthesis, structure evolution and in vitro bioactivity of collagen-silicocarnotite-chondroitin sulphate composites were presented.
Journal ArticleDOI
The influence of trace magnesium content on the phase composition of silicon-stabilized calcium phosphate powders
TL;DR: In this article, a novel silicon-stabilized calcium phosphate phase mixture possesses a characteristic phase composition of ∼75 ¾wt% silicon stabilized α-tricalcium phosphate (Si-α-TCP) with the balance being calcium hydroxyapatite (HA) and traces of β-tricallycium phosphate.
Journal ArticleDOI
Low-Cost Deposition of Antibacterial Ion-Substituted Hydroxyapatite Coatings onto 316L Stainless Steel for Biomedical and Dental Applications
Abdul Samad Khan,Muhammad Awais +1 more
TL;DR: In this article, the authors synthesized Mg, Zn, and Si-substituted hydroxyapatite (HA) using a microwave irradiation technique.
Journal ArticleDOI
Hydroxyapatite-silicon film deposited on Ti–Nb–10Zr by electrochemical and magnetron sputtering method
TL;DR: In this paper, the authors investigate silicon-doped hydroxyapatite (HA) films deposited on Ti-35Nb-10Zr by an electrochemical and magnetron sputtering method.
Journal ArticleDOI
In vitro behaviour of Nurse's Ass-phase: A new calcium silicophosphate ceramic
TL;DR: In this paper, a single phase Si-Ca-P-based ceramic (called Nurse's Ass) was obtained and its in vitro behavior was explored for potential bone tissue regeneration, showing that the new material supported adult human bone marrow-derived mesenchymal stem cells (hMSCs) adhesion and spreading, and cells came into close contact with the ceramic surface during an extended 28-day culture.
References
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Journal ArticleDOI
Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal ArticleDOI
Silicon: A Possible Factor in Bone Calcification
TL;DR: Silicon, a relatively unknown trace element in nutritional research, has been uniquely localized in active calcification sites in young bone and is suggested to be associated with calcium in an early stage of calcification.