Journal ArticleDOI
Chemical characterization of silicon-substituted hydroxyapatite.
TLDR
Chemical analysis confirmed the proposed substitution of the silicon (or silicate) ion for the phosphorus (or phosphate) ion in hydroxyapatite and demonstrated that phase-pure silicon-substituted hydroxyAPatite may be prepared using a simple precipitation technique.Abstract:
Bioceramic specimens have been prepared by incorporating a small amount of silicon (0.4 wt %) into the structure of hydroxyapatite [Ca10(PO4)6(OH)2, HA] via an aqueous precipitation reaction to produce a silicon-substituted hydroxyapatite (Si-HA). The results of chemical analysis confirmed the proposed substitution of the silicon (or silicate) ion for the phosphorus (or phosphate) ion in hydroxyapatite. The Si-HA was produced by first preparing a silicon-substituted apatite (Si-Ap) by a precipitation process. A single-phase Si-HA was obtained by heating/calcining the as-prepared Si-Ap to temperatures above 700 degrees C; no secondary phases, such as tricalcium phosphate (TCP), tetracalcium phosphate (TeCP), or calcium oxide (CaO), were observed by X-ray diffraction analysis. Although the X-ray diffraction patterns of Si-HA and stoichiometric HA appeared to be identical, refinement of the diffraction data revealed some small structural differences between the two materials. The silicon substitution in the HA lattice resulted in a small decrease in the a axis and an increase in the c axis of the unit cell. This substitution also caused a decrease in the number of hydroxyl (OH) groups in the unit cell, which was expected from the proposed substitution mechanism. The incorporation of silicon in the HA lattice resulted in an increase in the distortion of the PO4 tetrahedra, indicated by an increase in the distortion index. Analysis of the Si-HA by Fourier transform infrared (FTIR) spectroscopy indicated that although the amount of silicon incorporated into the HA lattice was small, silicon substitution appeared to affect the FTIR spectra of HA, in particular the P-O vibrational bands. The results demonstrate that phase-pure silicon-substituted hydroxyapatite may be prepared using a simple precipitation technique.read more
Citations
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Journal ArticleDOI
Revisiting silicate substituted hydroxyapatite by solid-state NMR.
Georgiana Gasqueres,Christian Bonhomme,Jocelyne Maquet,Florence Babonneau,Satoshi Hayakawa,Tomoko Kanaya,Akiyoshi Osaka +6 more
TL;DR: It is demonstrated here by solid‐state NMR spectroscopy that only a fraction of the silicon atoms are incorporated into the HAp lattice in the form of Q0 (SiO44−) species, for 4.6 wt% Si‐HAp.
Journal ArticleDOI
Effect of silicate doping on the structure and mechanical properties of thin nanostructured RF magnetron sputter-deposited hydroxyapatite films
Maria A. Surmeneva,T.M. Mukhametkaliyev,Alexander I. Tyurin,Anton D. Teresov,Nikolay N. Koval,T. S. Pirozhkova,I.A. Shuvarin,A. V. Shuklinov,Andrey O. Zhigachev,Christian Oehr,Roman A. Surmenev,Roman A. Surmenev +11 more
TL;DR: In this paper, the effect of Si doping on the structure and mechanical properties of thin HA films was evaluated using nanohardness testing and a scratch test, and the results showed that the addition of Si would affect the mechanical features of the coatings due to microstructure changes.
Journal ArticleDOI
Novel synthesis and structural characterization of fluorine and chlorine co-substituted hydroxyapatites
TL;DR: Characterization results from X-ray diffraction revealed that co-substitution of these anions resulted in the formation of pure HAP phase except for the small observed difference in the lattice parameters of the resultant apatites.
Journal ArticleDOI
Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures.
Vamsi V. Nagineni,Andrew R. James,Marjan Alimi,Christoph P. Hofstetter,Benjamin J. Shin,Innocent Njoku,Apostolos John Tsiouris,Roger Härtl +7 more
TL;DR: Si-CaP is an alternative to autogenous bone graft in spinal arthrodesis procedures and can be used as bone extender without any additional graft material, bone marrow aspirate, or bone morphogenetic protein in this series.
Journal ArticleDOI
Properties of osteoconductive biomaterials: calcium phosphate cement with different ratios of platelet-rich plasma as identifiers.
Chia-Ling Ko,Wen-Cheng Chen,Jian-Chih Chen,Ying Hui Wang,Chi-Jen Shih,Yu-Chang Tyan,Chun-Cheng Hung,Jen-Chyan Wang +7 more
TL;DR: CPC could be a potential carrier with adequate PRP additives that bear a therapeutic potential for enhanced bone tissue regeneration as well as proving its efficiency as bone graft substitutes in clinical restoration in vivo.
References
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Journal ArticleDOI
Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal ArticleDOI
Silicon: A Possible Factor in Bone Calcification
TL;DR: Silicon, a relatively unknown trace element in nutritional research, has been uniquely localized in active calcification sites in young bone and is suggested to be associated with calcium in an early stage of calcification.