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Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues
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TLDR
Dipartimento Farmaco-Chimico, Università diMessina, Via SS Annunziata, 98168 Messina, Italy, Dipartimenti di Scienze Chimiche, Universidad de Zaragoza, CSIC, and Laboratorio de Sintesis Asimetrica are investigating how Chimiche affects Quimica Organica.Abstract:
Dipartimento Farmaco-Chimico, Università di Messina, Via SS Annunziata, 98168 Messina, Italy, Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy, and Laboratorio de Sintesis Asimetrica, Departamento de Quimica Organica, Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza, CSIC, E-50009 Zaragoza, Aragon, Spain, Pedro Merino: pmerino@unizar.esread more
Citations
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Synthetic access to thiolane-based therapeutics and biological activity studies.
TL;DR: In this article, the development of important thiolane-based therapeutics such as (i) Nuphar sesquiterpene thioalkaloids (ii) Thiosugar sulphonium salts from Salacia sp. (iii) Albomycins (iv) 4'-thionucleosides summarizing various synthetic strategies, biosynthesis and biological activity studies.
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Nucleoside diphosphate sugar analogues that target glycosyltransferases
TL;DR: In this paper, the authors thank MINECO (Madrid, Spain), the FEDER Program (CTQ2013-44367-C2-1-P, CTQ2016-76155-R), and the Government of Aragon (Group E-10) for their support of their programs.
Journal ArticleDOI
Diastereoselective Synthesis of (1,3‐Dioxan‐4‐yl)pyrimidine and Purin Nucleoside Analogues
Umberto Maria Battisti,Claudia Sorbi,Antonio Quotadamo,Silvia Franchini,Annalisa Tait,Dominique Schols,Lak Shin Jeong,Sang Kook Lee,Jayoung Song,Livio Brasili +9 more
TL;DR: In this paper, the synthesis of 1,3-Dioxan-4-yl-substituted nucleoside analogues was carried out under Vorbruggen conditions in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) as a catalyst, with desired β-anomeric N-1 pyrimidine and N-9 purin nucleosides being obtained.
Journal ArticleDOI
N-Alkyl nitrones as substrates for access to N-aryl isoxazolidines via a catalyst-free one-pot three-component reaction with nitroso compounds and olefins
TL;DR: In this article, N-Alkyl nitrones are used as the starting materials to construct various N-aryl isoxazolidines, instead of N-alkyl isoxozolidines or N-H 1,3-oxazinanes via a catalyst-free one-pot three-component reaction with nitroso compounds and olefins.
Journal ArticleDOI
Regioselective and efficient synthesis of N 7-substituted adenines, guanines, and 6-mercaptopurines
TL;DR: The key step is the regioselective preparation of 7-substituted 6-chloropurines which are building blocks for the divergent synthesis of adenines, guanines, and 6-mercaptopurine by known procedures.
References
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Acyclic nucleoside phosphonates: a key class of antiviral drugs
Erik De Clercq,Antonín Holý +1 more
TL;DR: The discovery and development of acyclic nucleoside phosphonates is reviewed, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, and the prevention of HIV infections.
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New developments in the enantioselective synthesis of cyclopentyl carbocyclic nucleosides
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Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.
TL;DR: This review will discuss the major advances and future directions of the emerging field of antiviral and anticancer pronucleotide design and development.
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Nucleoside Analogues as Chemotherapeutic Agents: A Review
TL;DR: The importance of nucleoside analogues in chemotherapy and in other potential therapeutic approaches as immunomodulation or regulation of gene expression is reviewed in this paper, where the authors also present a review of the role of RNA-based methods.