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Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues
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TLDR
Dipartimento Farmaco-Chimico, Università diMessina, Via SS Annunziata, 98168 Messina, Italy, Dipartimenti di Scienze Chimiche, Universidad de Zaragoza, CSIC, and Laboratorio de Sintesis Asimetrica are investigating how Chimiche affects Quimica Organica.Abstract:
Dipartimento Farmaco-Chimico, Università di Messina, Via SS Annunziata, 98168 Messina, Italy, Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy, and Laboratorio de Sintesis Asimetrica, Departamento de Quimica Organica, Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza, CSIC, E-50009 Zaragoza, Aragon, Spain, Pedro Merino: pmerino@unizar.esread more
Citations
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Biocatalytic cascade transformations for the synthesis of C-nucleosides and N-nucleoside analogs.
Martin Pfeiffer,Bernd Nidetzky +1 more
TL;DR: Cascade biocatalysis is a powerful tool to obtain nucleosides from readily available starting materials as discussed by the authors , and recent efforts in enzyme discovery and protein engineering expand the toolbox of catalysts active toward nucleoside or nucleotides.
Journal ArticleDOI
Dideoxy nucleoside triphosphate (ddNTP) analogues: Synthesis and polymerase substrate activities of pyrrolidinyl nucleoside triphosphates (prNTPs).
TL;DR: The syntheses of rationally designed novel amino-functionalized ddNTP analogue such as Pyrrolidine nucleoside triphosphates (prNTPs), and their polymerase activities with DNA polymerase by LC-MS and Gel-electrophoretic techniques are described.
Journal ArticleDOI
Synthesis, Characterization and Antimicrobial Activity of New Nucleoside Analogues from Benzotriazole
TL;DR: The novel nucleoside analogues underwent a second condensation reaction with different aromatic and aliphatic amines to provide new Schiff bases and were tested against different bacteria to evaluate them as antimicrobial agents.
Journal ArticleDOI
An alternative method for the synthesis of 2'-halogeno-1',2'-unsaturated uridine derivatives through syn-elimination of pivalic acid of 2'-halogeno- 2'-deoxy-1'-pivaloyloxyuracil nucleoside: preparation of its 2'-C-branched nucleosides.
TL;DR: Compounds 5b and 5c were shown to serve as versatile synthons for the respective 2′-C-branched 1′,2′-unsaturated uracil nucleosides, through palladium-catalyzed cross-coupling or halogen-lithium exchange reactions.
References
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Acyclic nucleoside phosphonates: a key class of antiviral drugs
Erik De Clercq,Antonín Holý +1 more
TL;DR: The discovery and development of acyclic nucleoside phosphonates is reviewed, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, and the prevention of HIV infections.
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New developments in the enantioselective synthesis of cyclopentyl carbocyclic nucleosides
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Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.
TL;DR: This review will discuss the major advances and future directions of the emerging field of antiviral and anticancer pronucleotide design and development.
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Nucleoside Analogues as Chemotherapeutic Agents: A Review
TL;DR: The importance of nucleoside analogues in chemotherapy and in other potential therapeutic approaches as immunomodulation or regulation of gene expression is reviewed in this paper, where the authors also present a review of the role of RNA-based methods.