Journal ArticleDOI
Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues
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TLDR
Dipartimento Farmaco-Chimico, Università diMessina, Via SS Annunziata, 98168 Messina, Italy, Dipartimenti di Scienze Chimiche, Universidad de Zaragoza, CSIC, and Laboratorio de Sintesis Asimetrica are investigating how Chimiche affects Quimica Organica.Abstract:
Dipartimento Farmaco-Chimico, Università di Messina, Via SS Annunziata, 98168 Messina, Italy, Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy, and Laboratorio de Sintesis Asimetrica, Departamento de Quimica Organica, Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza, CSIC, E-50009 Zaragoza, Aragon, Spain, Pedro Merino: pmerino@unizar.esread more
Citations
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Journal ArticleDOI
Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation.
Yafei Cao,Min-Min Zhou,Min-Min Zhou,Runze Mao,You Zou,Feng Xia,Da-Ke Liu,Jianhui Liu,Qin Li,De-Cai Xiong,De-Cai Xiong,Xin-Shan Ye +11 more
TL;DR: In this paper, a new glycosylation method promoted by visible light with 3,5-dimethoxyphenyl glycoside as the donor was developed, which delivered both O-glycosides and N-glycolysis in moderate to excellent yields using a wide range of O-nucleophiles and nucleobases as the acceptors.
Journal ArticleDOI
Carbocyclic Ring Closure of Aryl C-Glycosides Promoted by Fluoroboric Acid
TL;DR: A novel transformation from rhamnose-type C-glycosides to 2-cyclopentenones is described, which underwent ring-opening and subsequent Nazarov cyclization to afford 2-Wikipediaenones in good to excellent yields.
Journal ArticleDOI
Synthesis of 1,2,3-Triazoles Bearing a 4-Hydroxyisoxazolidine Moiety from 4,5-Unsubstituted 2,3-Dihydroisoxazoles
Radka Štadániová,Michal Sahulčík,Jana Doháňošová,Ján Moncol,Ľuboš Janotka,Kristína Šimoničová,Lucia Messingerová,Lucia Messingerová,Róbert Fischer +8 more
Journal ArticleDOI
Carbocyclodipeptides as modified nucleosides: synthesis and anti-HIV activities
Bhupender S. Chhikara,M. Sudershan Rao,V. Kameshwara Rao,Anil Kumar,Karen W. Buckheit,Robert W. Buckheit,Keykavous Parang,Keykavous Parang,Keykavous Parang +8 more
TL;DR: A new class of nucleoside analogues were synthesized using cyclic dipeptides and modified 2′-deoxyfuranoribose sugars to introduce flexibility by peptides in place of common nucleosides bases.
Journal ArticleDOI
Synthesis of Nucleoside and Nucleotide Analogues by Cyclization of the Guanine Base with 1,1,3,3-Tetramethoxypropane.
TL;DR: This project developed a highly efficient method to synthesize M1dG and its analogues that has wide functional group tolerance, as various guanine-based nucleosides and nucleotides are suitable for the reaction.
References
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Acyclic nucleoside phosphonates: a key class of antiviral drugs
Erik De Clercq,Antonín Holý +1 more
TL;DR: The discovery and development of acyclic nucleoside phosphonates is reviewed, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, and the prevention of HIV infections.
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New developments in the enantioselective synthesis of cyclopentyl carbocyclic nucleosides
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Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.
TL;DR: This review will discuss the major advances and future directions of the emerging field of antiviral and anticancer pronucleotide design and development.
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Nucleoside Analogues as Chemotherapeutic Agents: A Review
TL;DR: The importance of nucleoside analogues in chemotherapy and in other potential therapeutic approaches as immunomodulation or regulation of gene expression is reviewed in this paper, where the authors also present a review of the role of RNA-based methods.