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Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues
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TLDR
Dipartimento Farmaco-Chimico, Università diMessina, Via SS Annunziata, 98168 Messina, Italy, Dipartimenti di Scienze Chimiche, Universidad de Zaragoza, CSIC, and Laboratorio de Sintesis Asimetrica are investigating how Chimiche affects Quimica Organica.Abstract:
Dipartimento Farmaco-Chimico, Università di Messina, Via SS Annunziata, 98168 Messina, Italy, Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy, and Laboratorio de Sintesis Asimetrica, Departamento de Quimica Organica, Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza, CSIC, E-50009 Zaragoza, Aragon, Spain, Pedro Merino: pmerino@unizar.esread more
Citations
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Synthesis and fungicidal activity of novel pyrazole derivatives containing 5-Phenyl-2-Furan.
TL;DR: Results suggested that the novel pyrazole derivatives proved to be promising lead compounds, and showed that compound I8 might act on the synthesis of cell walls from morphological and ultrastructural studies by SEM and TEM.
Journal ArticleDOI
Additive-Free Three-Component Synthesis of Spiro-isoxazolidine-oxindoles Employing Trifluorodiazoethane
TL;DR: An efficient three-component protocol for the synthesis of trifluoromethylated spiro-isoxazolidine-oxindoles has been developed and resulted in an interesting rearrangement to yield pyrroloquinoline derivatives.
Journal ArticleDOI
5',6'-nucleoside phosphonate analogues architecture: synthesis and comparative evaluation towards metabolic enzymes.
Franck Gallier,Julie A. C. Alexandre,Chahrazade El Amri,Dominique Deville-Bonne,Suzanne Peyrottes,Christian Périgaud +5 more
TL;DR: In this article, a series of ribonucleoside phosphonate derivatives isosteric to 5'-mononucleotides, with different degrees of flexibility within the 5',6'-C-C bond, as well as different polarities, through the introduction of hydroxy groups.
Journal ArticleDOI
Synthesis and biological evaluation of furopyrimidine N,O-nucleosides.
Roberto Romeo,Salvatore V. Giofrè,Adriana Garozzo,B. Bisignano,Antonino Corsaro,Maria A. Chiacchio +5 more
TL;DR: A series of modified N,O-nucleosides, characterized by the presence of a furopyrimidine moiety, has been synthesized by exploiting a Sonogashira cross coupling reaction of 1-isoxazolidinyl-5-iodouracil with alkynes, followed by treatment with CuI in refluxing TEA/MeOH mixture.
Journal ArticleDOI
C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.
Roberto Romeo,Caterina Carnovale,Salvatore V. Giofrè,Maria A. Chiacchio,Adriana Garozzo,Emanuele Amata,Giovanni Romeo,Ugo Chiacchio +7 more
TL;DR: Biological tests indicate an antitumor activity for the synthesized compounds: most of them inhibit cell proliferation of Vero, BS-C-1, HEp-2, MDCK, and HFF cells with a CC50 in the range of 5.0–40 μM.
References
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Acyclic nucleoside phosphonates: a key class of antiviral drugs
Erik De Clercq,Antonín Holý +1 more
TL;DR: The discovery and development of acyclic nucleoside phosphonates is reviewed, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, and the prevention of HIV infections.
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New developments in the enantioselective synthesis of cyclopentyl carbocyclic nucleosides
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Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.
TL;DR: This review will discuss the major advances and future directions of the emerging field of antiviral and anticancer pronucleotide design and development.
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Nucleoside Analogues as Chemotherapeutic Agents: A Review
TL;DR: The importance of nucleoside analogues in chemotherapy and in other potential therapeutic approaches as immunomodulation or regulation of gene expression is reviewed in this paper, where the authors also present a review of the role of RNA-based methods.