Journal ArticleDOI
Chemistry of Ketene N,S-Acetals: An Overview.
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TLDR
This review provides comprehensive knowledge on the chemistry of ketene N,S-acetals, which make them versatile and easy to use, especially in cyclization and multicomponent reactions for the synthesis of various heterocyclic systems and related natural products.Abstract:
Push–pull alkenes, which bear electron-donating and -accepting group(s) at both termini of a C═C double bond, respectively, are of interest not only for their unique electronic properties but also for their importance as versatile building blocks in organic synthesis. In the world of ketene acetals having the push–pull alkene skeleton, ketene N,S-acetal is most likely the biggest family according to the number and types of these compounds. The first ketene N,S-acetal compound was reported in 1956. As a cyclic ketene N,S-acetal compound, nithiazine, the first lead structure of neonicotinoid insecticides, was reported in 1978. The characteristics of ketene N,S-acetals, which have the structural feature of ketene S,S-acetals and enaminones, make them versatile and easy to use, especially in cyclization and multicomponent reactions for the synthesis of various heterocyclic systems and related natural products. There has been an increasing wealth of information about the synthesis and synthetic applications of...read more
Citations
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Journal ArticleDOI
Transition-metal mediated carbon-sulfur bond activation and transformations: an update.
Jiang Lou,Jiang Lou,Quannan Wang,Quannan Wang,Ping Wu,Ping Wu,Hongmei Wang,Yong-Gui Zhou,Zhengkun Yu,Zhengkun Yu +9 more
TL;DR: This review summarizes the advances in transition-metal-catalyzed cross-coupling via carbon-sulfur bond activation and cleavage since late 2012 as an update of the critical review on the same topic published in early 2013.
Journal ArticleDOI
Enaminones as Synthons for a Directed C-H Functionalization: Rh(III) -Catalyzed Synthesis of Naphthalenes
TL;DR: Proof-of-concept protocols have been developed for the Rh(III) -catalyzed synthesis of naphthalenes, based on the coupling of enaminones with either alkynes or α-diazo-β-ketoesters.
Journal ArticleDOI
Catalytic Asymmetric Reactions with N,O-Aminals
TL;DR: A wide array of catalytic asymmetric protocols involving the use of four distinct types of N,O-aminals as starting materials or key intermediates are introduced.
Journal ArticleDOI
Synthesis of β-Sulfonyl Amides through a Multicomponent Reaction with the Insertion of Sulfur Dioxide under Visible Light Irradiation.
TL;DR: This vicinal aminosulfonylation of styrenes with the insertion of sulfur dioxide under visible light irradiation proceeds efficiently with excellent chemoselectivity, giving rise to the corresponding β-sulfonyl amides in moderate to good yields.
Journal ArticleDOI
Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors.
Qëndresa Istrefi,Cüneyt Türkeş,Mustafa Arslan,Yeliz Demir,Arleta Rifati Nixha,Şükrü Beydemir,Ömer İrfan Küfrevioğlu +6 more
TL;DR: It is indicated that all compounds can inhibit metabolic dysfunctions, such as edema, epilepsy, glaucoma, and Alzheimer's disease, by specifically targeting both the hCA isoforms and AChE expression.
References
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