Journal ArticleDOI
Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats.
TLDR
The chemopreventive/chemotherapeutic effect of sodium selenite is found to be more effective in the initiation phase of carcinogenesis.Abstract:
The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N-nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) in hepatoma and surrounding tissues of hepatoma-bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose- and duration-dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis.read more
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Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats.
J Prince Vijeya Singh,Karuppaiyah Selvendiran,S. Mumtaz Banu,Radhakrishnan Padmavathi,Dhanapal Sakthisekaran +4 more
TL;DR: It is concluded that apigenin prevents LPO and protects antioxidant system in DEN induced and phenobarbital promoted hepatocellular carcinogenesis and protects oxidative stress caused by the carcinogen.
Journal ArticleDOI
Black Pepper and Health Claims: A Comprehensive Treatise
Masood Sadiq Butt,Imran Pasha,Muhammad Tauseef Sultan,Muhammad Atif Randhawa,Farhan Saeed,Waqas Ahmed +5 more
TL;DR: There is a need to conduct controlled randomized trials in human subjects, cohort studies, and meta-analyses to recommend the application of black pepper in diet-based regimens to prevent various ailments.
Journal ArticleDOI
Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
TL;DR: Piperine could effectively inhibit B(a)P-induced lung carcinogenesis in albino mice by offering protection from protein damage and also by suppressing cell proliferation.
Journal ArticleDOI
(-)Epigallocatechin-gallate (EGCG) prevents mitochondrial damage in isoproterenol-induced cardiac toxicity in albino Wistar rats: a transmission electron microscopic and in vitro study.
TL;DR: The preventive effect of EGCG on isoproterenol-induced mitochondrial damage in experimentally induced myocardial infarction in Wistar rats was confirmed and the observed effects are due to the free radical scavenging and antioxidant potential of E GCG.
Journal ArticleDOI
Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver.
Susan C. Tilton,Lena Gerwick,Jerry D. Hendricks,Caprice S. Rosato,Graham E. Corley-Smith,Scott A. Givan,George S. Bailey,Christopher J. Bayne,David E. Williams +8 more
TL;DR: A rainbow trout oligonucleotide array is developed containing 1672 elements representing over 1400 genes of known or probable relevance to toxicology, comparative immunology, carcinogenesis, endocrinology, and stress physiology to contribute to a better understanding of the mechanism of AFB(1)-induced hepatocarcinogenesis in trout.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
TL;DR: When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
Journal ArticleDOI
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial
Larry C. Clark,Gerald F. Combs,Bruce W. Turnbull,Elizabeth H. Slate,Dan K. Chalker,James Chow,Loretta S. Davis,Renee A. Glover,Gloria F. Graham,Earl G. Gross,Arnon Krongrad,Jack L. Lesher,H. Kim Park,Beverly B. Sanders,Cameron L. Smith,J. Richard Taylor +15 more
TL;DR: Results from secondary end-point analyses support the hypothesis that supplemental selenium may reduce the incidence of, and mortality from, carcinomas of several sites and require confirmation in an independent trial of appropriate design before new public health recommendations regarding seenium supplementation can be made.
Journal ArticleDOI
Chemopreventive agents: selenium.
Gerald F. Combs,William P. Gray +1 more
TL;DR: According to this two-stage model of the roles of Se in cancer prevention, individuals with nutritionally adequate Se intakes may benefit from Se supplementation and the development of the potential of Se compounds as cancer chemopreventive agents is facilitated.