Journal ArticleDOI
Chitosan-PVA-co-poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Hybrid IPN-Nanogels for Transdermal Delivery of Ondansetron; Synthesis, Characterization and Toxicological Evaluation
TLDR
Overall results were satisfactory concluding that prepared IPN-nanogels were stable with excellent drug permeation profile across skin, which aids in penetration of drugs through layers of skin into blood stream.Abstract:
Current study aimed to develop and evaluate interpenetrating polymer network (IPN) nanogels for transdermal delivery of ondansetron (OND) using combination of natural and synthetic polymers. Owing ...read more
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Journal ArticleDOI
Synthesis and Characterization of Carboxymethyl Chitosan Nanosponges with Cyclodextrin Blends for Drug Solubility Improvement
Syeda Nayab Batool Rizvi,Naveed Akhtar,Muhammad Usman Minhas,Arshad Mahmood,Kifayat Ullah Khan +4 more
TL;DR: In this paper , a nano-version of hydrogels with the additional qualities of both hydrogel and nano-systems was synthesized to enhance the solubility and release characteristics of docetaxel by synthesizing highly porous and stimuli responsive nanosponges.
Journal ArticleDOI
Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug's Solubility Improvement
Muhammad Usman Minhas,Kifayat Ullah Khan,Muhammad Sarfraz,Syed Badshah,Abubakar Munir,Kashif Barkat,Abdul Basit,Mosab Arafat +7 more
TL;DR: The developed PVP-K30-co-poly (AMPS) nanogel delivery system is expected to be safe, effective, and cost-effective for solubility improvement of poorly soluble drugs.
Journal ArticleDOI
Ondansetron/Cyclodextrin Inclusion Complex Nanofibrous Webs for Potential Orally Fast-Disintegrating Antiemetic Drug Delivery.
TL;DR: In this paper , the authors reported the electrospinning of polymer-free, free-standing Ondansetron/cyclodextrin (CD) nanofibrous webs (NW), a promising approach for developing a fast-disintegrating delivery system of an antiemetic drug molecule.
Journal ArticleDOI
Development and Evaluation of pH-Responsive Pluronic F 127 Co-Poly- (Acrylic Acid) Biodegradable Nanogels for Topical Delivery of Terbinafine HCL
TL;DR: In-vivo studies on rats infected with Candida albicans confirmed superiority of nanogels over 1% Lamisil for eradication of fungal infection and confirmed that TBH loaded in Pluronic F127 co-poly-(acrylic acid) nanogel provided greater targetibility and cure rates of poorly soluble TBH in animal model and hence Nanogels could be a potential carrier for effective topical delivery of TBH for skin fungal infections treatment.
Journal ArticleDOI
Synthesis and Evaluation of Finasteride-Loaded HPMC-Based Nanogels for Transdermal Delivery: A Versatile Nanoscopic Platform
Aous K. Ahmad,Mahmood Ahmad,Muhammad Usman Minhas,Muhammad Sarfraz,Muhammad Sohail,Kifayat Ullah Khan,Sana Tanveer,Shakeel Ijaz +7 more
TL;DR: It can be concluded that the developed nanogels were stable with excellent drug permeation profile across skin and ensured the biocompatibility of prepared nanocomposites.
References
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TL;DR: Chitin is the most abundant natural amino polysaccharide and is estimated to be produced annually almost as much as cellulose, and recent progress in chitin chemistry is quite noteworthy as mentioned in this paper.
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Design and applications of interpenetrating polymer network hydrogels. A review
TL;DR: In this paper, the authors give an overview of the recent design concepts of IPN hydrogels and their applications in controlled drug delivery, and separation processes, and a special concern is given to the macroporous IPN composite cryogels, which are very attractive materials for separation processes being endowed with a high reusability.
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Journal ArticleDOI
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