Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis
Claire Andrejak,Rikke Beck Nielsen,Vibeke Østergaard Thomsen,Pierre Duhaut,Henrik Toft Sørensen,Reimar W. Thomsen +5 more
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Chronic respiratory disease, particularly COPD treated with ICS therapy, is a strong risk factor for non-tuberculous mycobacterial pulmonary disease.Abstract:
Background Chronic respiratory disease and inhaled corticosteroid (ICS) therapy for chronic obstructive pulmonary disease (COPD) increase the risk of pneumonia. Few data are available on the association of these risk factors with non-tuberculous mycobacterial (NTM) pulmonary disease. Methods This study examined chronic respiratory diseases and ICS use as risk factors in a population-based case-control study encompassing all adults in Denmark with microbiologically confirmed NTM pulmonary disease between 1997 and 2008. The study included 10 matched population controls per case. Conditional logistic regression was used to compute adjusted ORs for NTM pulmonary disease with regard to chronic respiratory disease history. Results Overall, chronic respiratory disease was associated with a 16.5-fold (95% CI 12.2 to 22.2) increased risk of NTM pulmonary disease. The adjusted OR for NTM disease was 15.7 (95% CI 11.4 to 21.5) for COPD, 7.8 (95% CI 5.2 to 11.6) for asthma, 9.8 (95% CI 2.03 to 52.8) for pneumoconiosis, 187.5 (95% CI 24.8 to 1417.4) for bronchiectasis, and 178.3 (95% CI 55.4 to 574.3) for tuberculosis history. ORs were 29.1 (95% CI 13.3 to 63.8) for patients with COPD on current ICS therapy and 7.6 (95% CI 3.4 to 16.8) for patients with COPD who had never received ICS therapy. Among patients with COPD, ORs increased according to ICS dose, from 28.1 for low-dose intake to 47.5 for high-dose intake (more than 800 μg/day). The OR was higher for fluticasone than for budesonide. Conclusion Chronic respiratory disease, particularly COPD treated with ICS therapy, is a strong risk factor for NTM pulmonary disease.read more
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Nontuberculous mycobacterial lung disease in a patient with copd and bronchiectasis, with radiological signs of lung tumor
Dorota Wyrostkiewicz,Monika Szturmowicz,Iwona Bartoszuk,Izabela Siemion-Szcześniak,Lilia Jakubowska,Ewa Augustynowicz-Kopeć,Jan Kuś +6 more
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Eleonora Dehlink,Charlotte Richardson,Gemma Marsh,Kiralie Lee,Angela Jamalzadeh,Andrew Bush,Claire Hogg,Siobhán B. Carr +7 more
TL;DR: The aim of this cross-sectional single-centre study was to determine whether ICS prescriptions were targeted appropriately in PCD, which is a chronic suppurative lung disease characterised by abnormal mucociliary clearance due to genetic defects of motile cilia.
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Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases-Colonization or Disease?
Monika Szturmowicz,Karina Oniszh,Dorota Wyrostkiewicz,Piotr Radwan-Rohrenschef,Dorota Filipczak,Anna Zabost +5 more
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TL;DR: Risk factors, important diagnostic and treatment facts, and preventive measures to be taken to help improve outcomes of those infected with NTM infections are summarized.
References
More filters
Journal ArticleDOI
A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation☆
TL;DR: The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death fromComorbid disease for use in longitudinal studies and further work in larger populations is still required to refine the approach.
Journal ArticleDOI
An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.
David E. Griffith,Timothy R. Aksamit,Barbara A. Brown-Elliott,Antonino Catanzaro,Charles L. Daley,Fred M. Gordin,Steven M. Holland,Robert Horsburgh,Gwen A. Huitt,Michael F. Iademarco,Michael D. Iseman,Kenneth N. Olivier,Stephen J. Ruoss,C. Fordham von Reyn,Richard J. Wallace,Kevin L. Winthrop +15 more
TL;DR: Diagnostic Criteria of Nontuberculous Mycobacterial Lung Disease Key Laboratory Features of N TM Health Careand Hygiene-associated Disease Prevention Prophylaxis and Treatment of NTM Disease Introduction Methods.
Journal ArticleDOI
The Danish civil registration system
TL;DR: The Danish Civil Registration System (CRS) in connection with other registers and biobanks will continue to provide the basis for significant knowledge relevant to the aetiological understanding and possible prevention of human diseases.
Journal ArticleDOI
Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.
Julie A. Anderson,Bartolome R. Celli,Gary T. Ferguson,Christine Jenkins,Paul W. Jones,Julie C. Yates,Jørgen Vestbo +6 more
TL;DR: The reduction in death from all causes among patients with COPD in the combination-therapy group did not reach the predetermined level of statistical significance, and there were significant benefits in all other outcomes among these patients.
Journal Article
The Danish National Hospital Register. A valuable source of data for modern health sciences.
TL;DR: The Danish National Hospital Register is well suited to contribute to international comparative studies with relevance for evidence-based medicine, and how researchers may get access to the Register is described.
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