Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment
Gabriela Juszczyk,Joanna Mikulska,Kamila Kasperek,Diana Pietrzak,Weronika Mrozek,Mariola Herbet +5 more
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TLDR
In this paper, a review of the relationship between chronic stress, oxidative stress, and changes in the brain they cause occurring in Alzheimer's disease is presented, and the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium.Abstract:
There is a growing body of scientific research showing the link between depression and dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron.read more
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Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer's Disease
Fahadul Islam,Jannatul Fardous Khadija,M. Harun-or-Rashid,Md. Saidur Rahaman,Mohamed H Nafady,Md. Rezaul Islam,Aklima Akter,Talha Bin Emran,Polrat Wilairatana,Mohammad S. Mubarak +9 more
TL;DR: This article summarizes the literature pertaining to natural products as agents in the treatment of AD and focuses on natural products from plant sources and their derivatives that have demonstrated neuroprotective activities and maybe promising to treat and prevent AD.
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The Therapeutic Role of Ketogenic Diet in Neurological Disorders
TL;DR: KD can provide therapeutic benefits in patients with neurological problems by effectively controlling the balance between pro- and antioxidant processes and pro-excitatory and inhibitory neurotransmitters, and modulating inflammation or changing the composition of the gut microbiome.
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Disentangling Mitochondria in Alzheimer’s Disease
TL;DR: A review of the causative factors, as well as potential therapeutics employed in the treatment of Alzheimer's disease can be found in this article, where the authors discuss the benefits of restoration of mitochondrial bioenergetics, prevention of oxidative stress, and diet and exercise.
Journal ArticleDOI
Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease.
Mohsen Sheykhhasan,Razieh Amini,Sara Soleimani Asl,Massoud Saidijam,Seyed Mahmoud Hashemi,Rezvan Najafi +5 more
TL;DR: In this article , the effects of drug delivery of COQ10 by exosomes derived from adipose-derived stem cells (ADSCs-Exo) on cognition, memory, and neuronal proliferation in a rat model of Streptozotocin (STZ)-induced AD were investigated.
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Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships
TL;DR: In this paper, a series of imidazolylacetophenone oxime derivatives were constructed, and their C=N bonds were confirmed as the Z configuration by single crystals, showing potential multifunctional neuroprotective effects including anti-neuroinflammatory, antioxidative damage, metal-chelating, inhibition of acetylcholinesterase (AChE) properties.
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