Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis.
Junhua Wang,Ying Wang +1 more
TLDR
In this paper, the authors investigated DEX-induced protection on hippocampal neurons by targeting miR-28-3p and circ-CDR1as and found that DEX alleviated HT-22 cell dysfunction induced by H/R treatment.Citations
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The Role of miRNAs in Dexmedetomidine’s Neuroprotective Effects against Brain Disorders
Codrin-Constantin Burlacu,Maria Neag,Andrei Otto Mitre,Alexandru Sirbu,Andrei-Vlad Badulescu,Anca Dana Buzoianu +5 more
TL;DR: The neuroprotective effects of DEX are addressed by targeting miRNAs in modulating ischemic brain injury, ameliorating the neurotoxicity of anesthetics, reducing postoperative cognitive dysfunction, and improving the effects of neurodegenerative diseases.
Journal ArticleDOI
Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury
TL;DR: In this article , the microRNA-340-5p/DEAD-box helicase 5 axis was investigated in the context of cerebral ischemia-reperfusion-induced neuronal injury.
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Circ_0007706 downregulation ameliorates neonatal hypoxic ischemic encephalopathy via regulating the miR-579-3p/TRAF6 axis
TL;DR: In this paper , the functional role of circ_0007706 (circ_7706) in modulating neonatal hypoxic ischemic encephalopathy (HIE) was investigated.
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Physiological and pathological functions of circular RNAs in the nervous system
TL;DR: The role of Circular RNAs in brain development, maturity, and aging has been comprehensively reviewed in this article , where the authors focus on the involvement of circRNAs in various diseases of the central nervous system, such as brain cancer, chronic neurodegenerative diseases, acute injuries of the nervous system and neuropathic pain.
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Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats.
TL;DR: In this paper , the role of isoflurane in regulating autophagy and its regulatory mechanism on inflammation in CIRI are still unclear, and the authors used the middle cerebral artery occlusion (MCAO) method to establish a rat model of cerebral ischemic stroke (CIS) which predictably causes cerebral reperfusion.
References
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Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
TL;DR: In this paper, the authors used pre-clinical testing and appropriate selection of study participants to overcome the barriers to progress in acute ischemic stroke research, and proposed safe and effective treatment strategies that combine neuroprotection reperfusion, better use of advanced brain imaging for patient selection, and wider implementation of pre-hospital conducted clinical trials.
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The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression
TL;DR: Cdr1as also functioned as a powerful miR-7a sponge in myocardial cells, and showed regulation on the protective role of miR -7a in MI injury, involving the function of PARP and SP1.
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The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.
TL;DR: It is demonstrated that Cdr1as expression was upregulated in HCC tissues compared with the adjacent non-tumor tissues and knockdown of Cdr 1as suppressed the HCC cell proliferation and invasion through targeting miR-7.
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Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here.
Matthew K. Tobin,Jacqueline A. Bonds,Richard D. Minshall,Dale A. Pelligrino,Fernando D. Testai,Orly Lazarov +5 more
TL;DR: By understanding the interaction between inflammation and neurogenesis, new potential therapies could be developed to further establish brain repair mechanisms, and new treatment strategies need to be investigated.
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Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke
Bing Han,Yuan Zhang,Yanhong Zhang,Ying Bai,Xufeng Chen,Rongrong Huang,Fangfang Wu,Shuo Leng,Jie Chao,John H. Zhang,Gang Hu,Honghong Yao +11 more
TL;DR: The results of this study indicate thatcircHECTD1 and its coupling mechanism are involved in cerebral ischemia, thus providing translational evidence that circHectD1 can serve as a novel biomarker of and therapeutic target for stroke.