Orly Lazarov

TL;DR: Evidence is provided that environmental enrichment leads to reductions in steady-state levels of cerebral Abeta peptides and amyloid deposition and selective upregulation in levels of specific transcripts in brains of transgenic mice.

TL;DR: Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize and should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts.

TL;DR: Evidence that a reduction in neurogenesis underlies aging-related cognitive deficits and impairments in disorders such as Alzheimer's disease is considered, and knowledge of the underlying neurogenic signaling pathways could lead to novel therapeutic strategies for preserving brain function.

TL;DR: It is demonstrated that hippocampal neurogenesis is persistent through the tenth decade of life and is detectable in patients with mild cognitive impairments and Alzheimer's disease and that it is possibly associated with cognition.

TL;DR: Findings are consistent with the view that Aβ deposits are dynamic structures and that the perforant path lesion alters the equilibrium between Aβ production–deposition toward clearance as a consequence of blocked axonal transport of APP from the entorhinal cortex to terminal fields in the hippocampus.