Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults: Suspected Myocarditis After COVID-19 Vaccination
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In this article , the authors report on 139 adolescents and young adults with 140 episodes of suspected myocarditis (49 confirmed, 91 probable) at 26 centers, and they retrospectively collected data on patients <21 years old presenting before July 4, 2021.Citations
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2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis and Other Myocardial Involvement, Post-Acute Sequelae of SARS-CoV-2 Infection, and Return to Play
Ty J. Gluckman,Nicole M. Bhave,Larry A. Allen,Eugene H. Chung,Erica S. Spatz,Enrico Ammirati,Aaron L. Baggish,Biykem Bozkurt,William K. Cornwell,Kimberly G. Harmon,Jonathan H. Kim,Anuradha Lala,Benjamin D. Levine,Matthew W. Martinez,Oyere K Onuma,Dermot Phelan,Valentina O. Puntmann,Saurabh Rajpal,Pam R. Taub,Amanda K. Verma +19 more
TL;DR: CMR does not correlate particularly well with left ventricular ejection fraction (LVEF), nor with levels of cTn, natriuretic peptides, and C-reactive protein.
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Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex
TL;DR: A self-controlled case series study of people ages 13 years or older vaccinated for COVID-19 in England between December 1, 2020, and December 15, 2021, evaluated the association between vaccination and myocarditis, stratified by age and sex as mentioned in this paper .
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Incidence, risk factors, natural history, and hypothesised mechanisms of myocarditis and pericarditis following covid-19 vaccination: living evidence syntheses and review
Jennifer Pillay,L. Gaudet,Aireen Wingert,Liza Bialy,Andrew S. Mackie,D. Ian Paterson,Lisa Hartling +6 more
TL;DR: Findings indicate that adolescent and young adult men are at the highest risk of myocarditis after mRNA vaccination, with little direct supporting or refuting evidence.
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Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
TL;DR: In this paper , the authors performed extensive antibody profiling, including tests for SARS-CoV-2-specific humoral responses and assessment for autoantibodies or antibodies against the human-relevant virome, and cytokine and SARS antigen profiling, which revealed that the mRNA vaccine-induced immune responses did not differ between individuals who developed myocarditis and individuals who did not.
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Persistent Cardiac Magnetic Resonance Imaging Findings in a Cohort of Adolescents with Post-Coronavirus Disease 2019 mRNA Vaccine Myopericarditis
J. Schauer,Sujatha Buddhe,Avanti Gulhane,Eyal Sagiv,Matthew A. Studer,Jessica H. Colyer,Sathish Chikkabyrappa,Yuk M. Law,Michael A. Portman +8 more
TL;DR: In this paper , the authors describe the evolution of cardiac magnetic resonance imaging findings in 16 patients, aged 12-17 years, with myopericarditis after the second dose of the Pfizer mRNA coronavirus disease 2019 vaccine.
References
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Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases.
Alida L.P. Caforio,S. Pankuweit,Eloisa Arbustini,Cristina Basso,Juan Ramón Gimeno-Blanes,Stephan B. Felix,Michael Fu,Tiina Heliö,Stephane Heymans,Roland Jahns,Karin Klingel,Aleš Linhart,Bernhard Maisch,William J. McKenna,Jens Mogensen,Y. M. Pinto,Arsen D. Ristić,Heinz-Peter Schultheiss,Hubert Seggewiss,Luigi Tavazzi,Gaetano Thiene,Ali Yilmaz,Philippe Charron,Perry M. Elliott +23 more
TL;DR: The aims are to bridge the gap between clinical and tissue-based diagnosis, to improve management and provide a common reference point for future registries and multicentre randomised controlled trials of aetiology-driven treatment in inflammatory heart muscle disease.
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TL;DR: These recommendations provide updated and best evidence-based guidance to healthcare providers who diagnose and manage Kawasaki disease, but clinical decision making should be individualized to specific patient circumstances.
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Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations.
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TL;DR: This JACC Scientific Expert Panel provides consensus recommendations for an update of the cardiovascular magnetic resonance (CMR) diagnostic criteria for myocardial inflammation in patients with suspected acute or active myocardian inflammation (Lake Louise Criteria) that include options to use parametric mapping techniques.
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TL;DR: The emergence of multisystem inflammatory syndrome in children in New York State coincided with widespread SARS-CoV-2 transmission; this hyperinflammatory syndrome with dermatologic, mucocutaneous, and gastrointestinal manifestations was associated with cardiac dysfunction.
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The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Camila Rosat Consiglio,Nicola Cotugno,Nicola Cotugno,Fabian Sardh,Christian Pou,Donato Amodio,Donato Amodio,Lucie Rodriguez,Ziyang Tan,Sonia Zicari,Alessandra Ruggiero,Giuseppe Rubens Pascucci,Veronica Santilli,Tessa M. Campbell,Yenan T. Bryceson,Daniel Eriksson,Daniel Eriksson,Jun Wang,Alessandra Marchesi,Tadepally Lakshmikanth,Andrea Campana,Alberto Villani,Paolo Rossi,Paolo Rossi,Nils Landegren,Nils Landegren,Paolo Palma,Paolo Palma,Petter Brodin,Petter Brodin +29 more
TL;DR: The inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage.