C
Christian Pou
Researcher at Science for Life Laboratory
Publications - 34
Citations - 2669
Christian Pou is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Population & Raltegravir. The author has an hindex of 16, co-authored 30 publications receiving 1322 citations. Previous affiliations of Christian Pou include Karolinska Institutet & Autonomous University of Barcelona.
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Journal ArticleDOI
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Camila Rosat Consiglio,Nicola Cotugno,Nicola Cotugno,Fabian Sardh,Christian Pou,Donato Amodio,Donato Amodio,Lucie Rodriguez,Ziyang Tan,Sonia Zicari,Alessandra Ruggiero,Giuseppe Rubens Pascucci,Veronica Santilli,Tessa M. Campbell,Yenan T. Bryceson,Daniel Eriksson,Daniel Eriksson,Jun Wang,Alessandra Marchesi,Tadepally Lakshmikanth,Andrea Campana,Alberto Villani,Paolo Rossi,Paolo Rossi,Nils Landegren,Nils Landegren,Paolo Palma,Paolo Palma,Petter Brodin,Petter Brodin +29 more
TL;DR: The inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage.
Journal ArticleDOI
Stereotypic Immune System Development in Newborn Children
Axel Olin,Ewa Henckel,Yang Chen,Tadepally Lakshmikanth,Christian Pou,Jaromír Mikeš,Anna Gustafsson,Anna Gustafsson,Anna Karin Bernhardsson,Cheng Zhang,Kajsa Bohlin,Kajsa Bohlin,Petter Brodin,Petter Brodin +13 more
TL;DR: This article performed longitudinal analyses in 100 newborn children, sampled up to 4 times during their first 3 months of life, and analyzed the development of 58 immune cell populations by mass cytometry and 267 plasma proteins by immunoassays.
Posted ContentDOI
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Camila Rosat Consiglio,Nicola Cotugno,Nicola Cotugno,Fabian Sardh,Christian Pou,Donato Amodio,Donato Amodio,Lucie Rodriguez,Ziyang Tan,Sonia Zicari,Alessandra Ruggiero,Giuseppe Rubens Pascucci,Veronica Santilli,Tessa M. Campbell,Yenan T. Bryceson,Daniel Eriksson,Daniel Eriksson,Jun Wang,Alessandra Marchesi,Tadepally Lakshmikanth,Andrea Campana,Alberto Villani,Paolo Rossi,Paolo Rossi,Nils Landegren,Nils Landegren,Paolo Palma,Paolo Palma,Petter Brodin,Petter Brodin +29 more
TL;DR: The inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, is more similar to Kawasaki disease, but also differ from this with respect to T-cell subsets, IL-17A and biomarkers associated with arterial damage.
Journal ArticleDOI
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
Mathias Uhlén,Mathias Uhlén,Mathias Uhlén,Max J. Karlsson,Wen Zhong,Abdellah Tebani,Christian Pou,Jaromír Mikeš,Tadepally Lakshmikanth,Björn Forsström,Fredrik Edfors,Jacob Odeberg,Jacob Odeberg,Adil Mardinoglu,Adil Mardinoglu,Cheng Zhang,Kalle von Feilitzen,Jan Mulder,Evelina Sjöstedt,Andreas Hober,Per Oksvold,Martin Zwahlen,Fredrik Pontén,Cecilia Lindskog,Åsa Sivertsson,Linn Fagerberg,Petter Brodin,Petter Brodin +27 more
TL;DR: The cellular distribution of genes known to cause primary immunodeficiencies in humans are shown and find that many of these genes are expressed in cells not currently implicated in these diseases, illustrating how this global atlas can help us better understand the function of specific genes across cells and tissues in humans.
Journal ArticleDOI
Bifidobacteria-mediated immune system imprinting early in life.
Bethany M. Henrick,Lucie Rodriguez,Tadepally Lakshmikanth,Christian Pou,Ewa Henckel,Ewa Henckel,Ewa Henckel,Aron Arzoomand,Axel Olin,Jun Wang,Jaromír Mikeš,Ziyang Tan,Yang Chen,Amy M. Ehrlich,Anna Karin Bernhardsson,Constantin Habimana Mugabo,Ylva Ambrosiani,Anna Gustafsson,Anna Gustafsson,Stephanie Chew,Heather Brown,Johann Prambs,Kajsa Bohlin,Kajsa Bohlin,Ryan D. Mitchell,Mark A. Underwood,Jennifer T. Smilowitz,J. Bruce German,Steven A. Frese,Steven A. Frese,Petter Brodin,Petter Brodin +31 more
TL;DR: This article showed that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life.