Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): Tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development
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TLDR
RT-PCR analysis revealed that gene expression of three steroidogenic enzyme show distinctly different tissue-specific patterns of expression in the Japanese eel, suggesting that some steroidogenic enzymes are also expressed in non-endocrine tissues and could potentially regulate the local and/or circulating steroid levels in teleosts, as they do in mammals.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2006-05-01 and is currently open access. It has received 42 citations till now. The article focuses on the topics: Cholesterol side-chain cleavage enzyme & Japanese eel.read more
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Journal ArticleDOI
Cytochrome P450 (CYP) in fish.
TL;DR: An overview of the CYP families in fish is presented, focusing on eight families that have been studied in detail and provided insights into the regulation of P450 genes by environmental stresses including water pollution.
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Novel activities of CYP11A1 and their potential physiological significance
Andrzej Slominski,Wei Li,Tae Kang Kim,Igor Semak,Jin Wang,Jordan K. Zjawiony,Robert C. Tuckey +6 more
TL;DR: CYP11A1-derived secosteroidal hydroxy-derivatives and Δ(7)steroids are biologically active when administered in vitro in a manner dependent on the structure of the compound and the lineage of the target cells, suggesting physiological roles for these metabolites.
Journal ArticleDOI
Steroids in teleost fishes: A functional point of view
TL;DR: The steroidogenesis, hormone receptors, and function of the steroid hormones are reasonably well understood when summarizing the available data of all teleost species analyzed to date, however, on the level of a single species or a certain fish-specific aspect of physiology, further research is needed.
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Japanese Eel Follicle-Stimulating Hormone (Fsh) and Luteinizing Hormone (Lh): Production of Biologically Active Recombinant Fsh and Lh by Drosophila S2 Cells and Their Differential Actions on the Reproductive Biology
Yukinori Kazeto,Mayuko Kohara,Takeshi Miura,Chiemi Miura,Sonoko Yamaguchi,John M. Trant,Shinji Adachi,Kohei Yamauchi +7 more
TL;DR: The data strongly suggest that Fsh and Lh differentially play important roles in the reproductive physiology of the Japanese eel, which is probably due to the qualitative nature of glycosylation in S2 cells, which resulted in degradation of the recombinant protein in vivo.
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Maternal investment in fish oocytes and eggs: The molecular cargo and its contributions to fertility and early development
TL;DR: Significant advances have been made in revealing the molecular mechanisms of lipid accumulation and metabolism within the oocyte, the intricacies of yolk protein formation via endocytosis of multiple yolk precursor proteins by multiple oocyte receptors, and the complex machinery supporting massive accumulation of water by maturing oocytes of many species.
References
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The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Naruya Saitou,Masatoshi Nei +1 more
TL;DR: The neighbor-joining method and Sattath and Tversky's method are shown to be generally better than the other methods for reconstructing phylogenetic trees from evolutionary distance data.
Journal Article
Aromatase expression in health and disease
Evan R. Simpson,Ying Zhao,Veena R. Agarwal,M. Dodson Michael,Serdar E. Bulun,Margaret M. Hinshelwood,Sandra E. Graham-Lorence,Tiejun Sun,Carolyn R. Fisher,Kenan Qin,Carole R. Mendelson +10 more
TL;DR: Family 19 of the P450 superfamily is responsible for the conversion of C19 androgenic steroids to the corresponding estrogens, a reaction known as aromatization, since it involves conversion of the delta 4-3-one A-ring of the androgens to the corresponds phenolic A- ring characteristic of estrogens.
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Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta
TL;DR: P450sCC cDNA was used to probe DNA from a panel of mouse-human somatic cell hybrids, showing that the single human P450scc gene lies on chromosome 15, and primary cultures of placental tissue indicate P 450scc mRNA accumulates in response to cyclic AMP.
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Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development.
TL;DR: In this article, a PCR cloning strategy was used to isolate complementary DNAs encoding two distinct cytochrome P450 aromatase isoforms in adult zebrafish brain and ovary (termed P450aromB and P450aramA, respectively).
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Identification of maturation-inducing steroid in a teleost, the amago salmon (Oncorhynchus rhodurus)☆
Yoshitaka Nagahama,Shinji Adachi +1 more
TL;DR: In this paper, the maturation-inducing activity of residues at various steps of purification was assessed by an in vitro germinal vesicle breakdown (GVBD) assay based on fully grown prophase-arrested folliculated oocytes of amago salmon.