Journal ArticleDOI
Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity.
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TLDR
The results provide further support to explain the traditional use of W. coagulans as antihyperglycemic cum antidyslipidemic agent by the traditional medical practitioners.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2008-12-15. It has received 69 citations till now. The article focuses on the topics: Withania coagulans & Withania.read more
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Journal ArticleDOI
Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.
TL;DR: An overview of the chemical structures of triterpenoid components and their biological activity is presented, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimer's disease.
Journal ArticleDOI
Antidiabetic Potential of Medicinal Plants and Their Active Components.
Bahare Salehi,Athar Ata,Nanjangud V. Anil Kumar,Farukh Sharopov,Karina Ramírez-Alarcón,Ana M. Ruiz-Ortega,Seyed Abdulmajid Ayatollahi,Patrick Valere Tsouh Fokou,Farzad Kobarfard,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Marcello Iriti,Yasaman Taheri,Miquel Martorell,Antoni Sureda,William N. Setzer,Alessandra Durazzo,Massimo Lucarini,Antonello Santini,Raffaele Capasso,Elise Adrian Ostrander,Atta-ur-Rahman,Muhammad Iqbal Choudhary,William C. Cho,Javad Sharifi-Rad +24 more
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
Journal ArticleDOI
Natural withanolides: an overview
Li-Xia Chen,Hao He,Feng Qiu +2 more
TL;DR: This review provides a comprehensive summary of the structural classification and distribution of these new compounds of naturally occurring withanolides.
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Recent discovery of plant-derived anti-diabetic natural products
Hsin Yi Hung,Keduo Qian,Susan L. Morris-Natschke,Chau Shin Hsu,Kuo Hsiung Lee,Kuo Hsiung Lee +5 more
TL;DR: In this review, recent discoveries of anti-diabetic compounds have been summarized according to their chemical structures and mechanisms of action.
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Anti-diabetic agents from natural products--an update from 2004 to 2009.
TL;DR: NPs appeared in the literature with potential for DM and also identifies the research needs in this area, which mainly covers the time period from January 2004 to October 2008.
References
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Journal ArticleDOI
Constituents of Withania somnifera Dun. III. The Side Chain of Withaferin A*,1
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Antifungal steroidal lactones from Withania coagulance.
TL;DR: Two new withanolides, 14,15 beta-epoxy withanolide I and 17 beta-hydroxywithanolide K, have been isolated from the whole plant of Withania coagulance and their structures were elucidated by spectroscopic techniques.
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Hypoglycemic activity of Withania coagulans Dunal in streptozotocin induced diabetic rats.
TL;DR: Administration of aqueous extract of fruits of Withania coagulans Dunal significantly lowered the blood sugar, serum cholesterol, serum LPO, and hepatic LPO levels at the highest concentration of 1g/kg in streptozotocin induced diabetic rats.
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Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats.
TL;DR: Administration of an aqueous extract of fruits of Withania coagulans to high fat diet induced hyperlipidemic rats for 7 weeks, significantly reduced elevated serum cholesterol, triglycerides and lipoprotein levels.