BookDOI
Collagen : structure and mechanics
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TLDR
This chapter discusses Collagen and the Mechanical Properties of Bone and Calcified Cartilage, as well as biomimetic Collagen Tissues: Collagenous Tissue Engineering and Other Applications.Abstract:
Collagen: Structure and Mechanics, an Introduction.- Collagen Diversity, Synthesis and Assembly.- Collagen Fibrillar Structure and Hierarchies.- Restraining Cross-Links Responsible for the Mechanical Properties of Collagen Fibers: Natural and Artificial.- Damage and Fatigue.- Viscoelasticity, Energy Storage and Transmission and Dissipation by Extracellular Matrices in Vertebrates.- Nanoscale Deformation Mechanisms in Collagen.- Hierarchical Nanomechanics of Collagen Fibrils: Atomistic and Molecular Modeling.- Mechanical Adaptation and Tissue Remodeling.- Tendons and Ligaments: Structure, Mechanical Behavior and Biological Function.- Collagen in Arterial Walls: Biomechanical Aspects.- The Extracellular Matrix of Skeletal and Cardiac Muscle.- The Cornea and Sclera.- Collagen and the Mechanical Properties of Bone and Calcified Cartilage.- Dentin.- Genetic Collagen Diseases: Influence of Collagen Mutations on Structure and Mechanical Behavior.- Biomimetic Collagen Tissues: Collagenous Tissue Engineering and Other Applications.read more
Citations
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Journal ArticleDOI
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Jazli Aziz,Hafiz Shezali,Zamri Radzi,Noor Azlin Yahya,Noor Hayaty Abu Kassim,Jan T. Czernuszka,Mohammad Tariqur Rahman +6 more
TL;DR: This review paper proposes a model which elucidates how these molecular pathways intersect with one another, and how various internal and external factors can disrupt these pathways, ultimately leading to a disruption in collagen and elastin networks.
Journal ArticleDOI
Biological materials: Functional adaptations and bioinspired designs
TL;DR: In this paper, the authors conduct an analysis connecting the structure (nano, micro, meso, and macro) to the mechanical properties important for a specific function, and address how biological systems respond and adapt to external mechanical stimuli.
Journal ArticleDOI
Cell-mediated Fibre Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments
Brendon M. Baker,Britta Trappmann,Britta Trappmann,William Y. Wang,Mahmut Selman Sakar,Iris L. Kim,Vivek B. Shenoy,Jason A. Burdick,Christopher S. Chen,Christopher S. Chen +9 more
TL;DR: A departure from the well-described relationship between material stiffness and spreading established with hydrogel surfaces is demonstrated, and fiber recruitment is introduced as a novel mechanism by which cells probe and respond to mechanics in fibrillar matrices.
Journal ArticleDOI
Molecular mechanics of mineralized collagen fibrils in bone.
TL;DR: The results suggest that the mineral crystals within this network bears up to four times the stress of the collagen fibrils, whereas the collagen is predominantly responsible for the material’s deformation response.
Journal ArticleDOI
Plasticity and toughness in bone
TL;DR: Our bones are full of microscopic cracks, but the hierarchical character of the bones' structure makes them remarkably resistant to fracture as mentioned in this paper, from molecular to macroscopic scales, which makes them resilient to fracture.