Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells
Hee Jin Lee,Dae-Woon Eom,Gil Hyun Kang,Sang Hak Han,Gab Jin Cheon,Ho-Suk Oh,Koon Hee Han,Heui June Ahn,Hyuk-Jai Jang,Myoung Sik Han +9 more
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TLDR
Recognition of the micropapillary carcinoma component in colonic adenocarcinoma is very important, because themicropapilla carcinoma has been associated with a significantly worse prognosis.About:
This article is published in Modern Pathology.The article was published on 2013-08-01 and is currently open access. It has received 54 citations till now. The article focuses on the topics: Carcinoma & Adenocarcinoma.read more
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Accuracy of TNM staging in colorectal cancer: a review of current culprits, the modern role of morphology and stepping-stones for improvements in the molecular era.
TL;DR: The current role of histopathology, controversies in TNM-staging and suggested alternatives to better predict outcome for CRC patients in the era of genomic medicine are reviewed.
Journal ArticleDOI
Prognostic stratification of colorectal cancer patients: current perspectives.
Nora I. Schneider,Cord Langner +1 more
TL;DR: The histological features of colorectal cancer that can be used for prognostic stratification are summarized and a lack of standardization prevented its application in routine pathology, but scales to assess intra- and peritumoral inflammation can be expected to strengthen the prognostic significance of the pathology report.
Journal ArticleDOI
Micropapillary pattern and poorly differentiated clusters represent the same biological phenomenon in colorectal cancer: a proposal for a change in terminology.
TL;DR: The altered expression of MUC1 and E-cadherin may account for the aggressive behavior and higher metastatic potential of CRCs with high PDC counts and indicate an epithelial-mesenchymal transition.
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Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: effect of neoadjuvant chemotherapy on local recurrence.
Souichi Yanamoto,Shin-ichi Yamada,Hidenori Takahashi,Tomofumi Naruse,Yuki Matsushita,Hisazumi Ikeda,Takeshi Shiraishi,Sachiko Seki,Shuichi Fujita,Tohru Ikeda,Izumi Asahina,Masahiro Umeda +11 more
TL;DR: It is proposed that NAC leads to the selection and/or residue of more aggressive cancer stem-like cells in NAC-treated cases and is a significant independent predictive factor of the 5-year disease specific survival.
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The Role of Notch3 in Cancer.
TL;DR: The role of Notch3 in cancer, possible mechanisms of its action, and current cancer treatment strategies targeting notch3 signaling are summarized.
References
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AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Cancer statistics, 2007.
TL;DR: While the absolute number of cancer deaths decreased for the second consecutive year in the United States, much progress has been made in reducing mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years.
Journal Article
Identification of a Cancer Stem Cell in Human Brain Tumors
Sheila K. Singh,Ian D. Clarke,Mizuhiko Terasaki,Victoria E. Bonn,Cynthia Hawkins,Jeremy A. Squire,Peter B. Dirks +6 more
TL;DR: The identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation is reported.
Journal ArticleDOI
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Tsvee Lapidot,Christian Sirard,Josef Vormoor,Barbara Murdoch,Trang Hoang,Julio R. Caceres-Cortes,Mark D. Minden,Bruce Paterson,Michael A. Caligiuri,John E. Dick +9 more
TL;DR: This in vivo model replicates many aspects of human AML and defines a new leukaemia-initiating cell which is less mature than colony-forming cells.