Journal ArticleDOI
Combating enterovirus replication: state-of-the-art on antiviral research.
TLDR
Several viral proteins, such as the viral 3C protease, the putative 2C helicase and the 3D RNA-dependent RNA polymerase may be/are excellent targets for inhibition of viral replication.About:
This article is published in Biochemical Pharmacology.The article was published on 2012-01-15. It has received 138 citations till now. The article focuses on the topics: Pleconaril & Viral replication.read more
Citations
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The life cycle of non-polio enteroviruses and how to target it.
TL;DR: This Review summarizes recent insights from enterovirus research with a special emphasis on NPEVs, and reflects on how recent discoveries may help in the development of new antiviral strategies.
Journal ArticleDOI
Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects.
TL;DR: It is demonstrated that physico-chemical interference with host pathways has broad range antiviral effects, and provides a proof of concept for the development of host-directed antivirals.
Journal ArticleDOI
The enteroviruses: problems in need of treatments.
TL;DR: Poliomyelitis, EV 71 neurologic disease, and neonatal EV disease are three manifestations of EV infections that exemplify the importance of developing antivirals for EV infections and illustrate why development of antiviral medications for EVs infections is a medically important need.
Journal ArticleDOI
A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ
Hilde M. van der Schaar,Pieter Leyssen,Hendrik Jan Thibaut,Armando M. De Palma,Lonneke van der Linden,Lonneke van der Linden,Kjerstin Lanke,Céline Lacroix,Erik Verbeken,Katja Conrath,Angus M Macleod,Dale Robert Mitchell,Nicholas John Palmer,Hervé Van de Poël,Martin James Inglis Andrews,Johan Neyts,Frank J. M. van Kuppeveld,Frank J. M. van Kuppeveld +17 more
TL;DR: A novel inhibitor of enterovirus replication, compound 1, 2-fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, is well tolerated in mice and has a dose-dependent protective activity in a coxsackievirus serotype B4-induced pancreatitis model.
Journal ArticleDOI
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Aurelie Mousnier,Aurelie Mousnier,Andrew Simon Bell,Dawid Swieboda,Julia Morales-Sanfrutos,Inmaculada Pérez-Dorado,James A. Brannigan,Joseph Newman,Markus Ritzefeld,J.A. Hutton,Anabel Guedán,Amin S. Asfor,Sean Robinson,Iva Hopkins-Navratilova,Anthony J. Wilkinson,Sebastian L. Johnston,Robin J. Leatherbarrow,Robin J. Leatherbarrow,Tobias J. Tuthill,Roberto Solari,Edward W. Tate +20 more
TL;DR: IMP-1088 is used to demonstrate that pharmacological inhibition of host-cell N-myristoylation rapidly and completely prevents rhinoviral replication without inducing cytotoxicity, and to deliver a low nanomolar antiviral activity against multiple RV strains, poliovirus and foot and-mouth disease virus, and protection of cells against virus-induced killing.
References
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Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C
John G. McHutchison,Stuart C. Gordon,Eugene R. Schiff,Mitchell L. Shiffman,William M. Lee,Vinod K. Rustgi,Zachary Goodman,Mei Hsiu Ling,Susannah Cort,Janice K. Albrecht +9 more
TL;DR: In patients with chronic hepatitis C, initial therapy withinterferon and ribavirin was more effective than treatment with interferon alone.
Journal ArticleDOI
Structure of a human common cold virus and functional relationship to other picornaviruses
Michael G. Rossmann,Edward Arnold,John W. Erickson,Elizabeth A. Frankenberger,James P. Griffith,Hans-Jürgen Hecht,John E. Johnson,Greg Kamer,Ming Luo,Anne G. Mosser,Roland R. Rueckert,Barbara Sherry,Gerrit Vriend +12 more
TL;DR: The first atomic resolution structure of an animal virus, human rhinovirus 14, strikingly similar to known icosahedral plant RNA viruses, and four neutralizing immunogenic regions have been identified.
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The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen.
Shane Crotty,David Maag,Jamie J. Arnold,Weidong Zhong,Johnson Y. N. Lau,Zhi Hong,Raul Andino,Craig E. Cameron +7 more
TL;DR: In vitro use of ribavirin triphosphate by a model viral RNA polymerase, poliovirus 3Dpol, indicates that ribvirin forces the virus into `error catastrophe' and mutagenic ribonucleosides may represent an important class of anti-RNA virus agents.
Journal ArticleDOI
Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication
Nai Yun Hsu,Olga Ilnytska,Georgiy Belov,Marianita Santiana,Ying-Han Chen,Peter M. Takvorian,Cyrilla Pau,Hilde M. van der Schaar,Neerja Kaushik-Basu,Tamas Balla,Craig E. Cameron,Ellie Ehrenfeld,Frank J. M. van Kuppeveld,Nihal Altan-Bonnet +13 more
TL;DR: It is shown how RNA viruses can manipulate multiple components of the cellular secretory pathway to generate organelles specialized for replication that are distinct in protein and lipid composition from the host cell.
Journal ArticleDOI
Evolutionary families of peptidase inhibitors.
TL;DR: A system wherein the inhibitor units of the peptidase inhibitors are assigned to 48 families on the basis of similarities detectable at the level of amino acid sequence, and a simple system of nomenclature is introduced for reference to each clan, family and inhibitor.