Book ChapterDOI
Comparative Analysis of Striatal FDOPA Uptake in Parkinson's Disease
Vijay Dhawan,Yilong Ma,Vandhana Pillai,Phoebe G. Spetsieris,Thomas Chaly,David Eidelberg +5 more
- pp 285-289
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TLDR
It is suggested that SOR determined from a single 10-min scan at 95 min is as accurate as K(i)(occ) in separating PD patients from healthy subjects and in predicting clinical measures of disease severity.About:
The article was published on 2002-01-01. It has received 78 citations till now. The article focuses on the topics: Parkinson's disease.read more
Citations
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Journal ArticleDOI
EFNS/MDS‐ES recommendations for the diagnosis of Parkinson's disease
Alfredo Berardelli,Gregor K. Wenning,Angelo Antonini,Daniela Berg,B.R. Bloem,Vincenzo Bonifati,David J. Brooks,David J. Burn,Carlo Colosimo,Alessandra Fanciulli,Joaquim J. Ferreira,Thomas Gasser,Francisco Grandas,Petr Kanovsky,Vladimir S. Kostic,Jaime Kulisevsky,Wolfgang H. Oertel,Werner Poewe,Jens P. Reese,Maja Relja,Evzem Ruzicka,A Schrag,Klaus Seppi,Pille Taba,Marie Vidailhet +24 more
TL;DR: A Task Force was convened by the EFNS/MDS‐ES Scientist Panel on Parkinson's disease and other movement disorders to systemically review relevant publications on the diagnosis of PD.
Journal ArticleDOI
Results from a phase I safety trial of hAADC gene therapy for Parkinson disease
Jamie L. Eberling,William J. Jagust,Chadwick W. Christine,Philip A. Starr,Paul S. Larson,Krystof S. Bankiewicz,Michael J. Aminoff +6 more
TL;DR: These initial findings demonstrate the safety of the therapy; higher doses of adeno-associated viral vector containing the human aromatic l-amino acid decarboxylase gene in the next cohort of patients may further increase dopamine production in the putamen and provide more profound clinical benefit.
Journal ArticleDOI
The role of radiotracer imaging in Parkinson disease
Bernard Ravina,David Eidelberg,J. E. Ahlskog,Roger L. Albin,David J. Brooks,Maren Carbon,Vijay Dhawan,Andrew Feigin,Stanley Fahn,Mark Guttman,Katrina Gwinn-Hardy,Henry F. McFarland,Robert B. Innis,Russell Katz,Karl Kieburtz,Stephen J. Kish,N. Lange,J. W. Langston,Kenneth Marek,L. Morin,Claudia S. Moy,Declan G. Murphy,Wolfgang H. Oertel,G. Oliver,Yuko Y. Palesch,William J. Powers,John Seibyl,Kapil D. Sethi,Clifford W. Shults,P. Sheehy,A. J. Stoessl,Robert G. Holloway +31 more
TL;DR: In this paper, the authors review the concepts of biomarker development and the evidence to support the use of four radiotracers as biomarkers in Parkinson disease: [18 F]fluorodopa PET, (+)-[ 11 C]dihydrotetrabenazine PET, [ 123 I]β-CIT SPECT, and [ 18 F]-fluorodeoxyglucose PET.
Journal ArticleDOI
Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease.
David J. Brooks,Kirk A. Frey,Kenneth Marek,David Oakes,D Paty,R Prentice,Clifford W. Shults,A J Stoessl +7 more
TL;DR: During the 54(th) Annual Meeting of the American Academy of Neurology, a group of investigators active in the fields of biomakers, neuroimaging, and neuroprotection met to review the three techniques mentioned above and developed consensus on a set of 10 criteria for a neuroim imaging technique to be considered adequate as a biomarker for progression of PD.
Journal ArticleDOI
Dopamine Cell Implantation in Parkinson's Disease: Long-Term Clinical and 18F-FDOPA PET Outcomes
Yilong Ma,Chengke Tang,Thomas Chaly,Paul Greene,Robert E. Breeze,Stanley Fahn,Curt R. Freed,Vijay Dhawan,David Eidelberg +8 more
TL;DR: Clinical benefit and graft viability are sustained up to 4 y after transplantation, and the dependence of clinical (but not imaging) outcomes on subject age and sex at 1 y may not persist over the long term.
References
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Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
Journal ArticleDOI
Measuring the rate of progression and estimating the preclinical period of Parkinson’s disease with [18F]dopa PET
TL;DR: Estimation of mean rate of progression varies according to the sensitivity of a functional imaging method to clinical severity, and putamen Ki was the most sensitive measure of disease progression, caudate ratio the least.