Journal ArticleDOI
Comparative Genomic Analysis of Genes Encoding Translation Elongation Factor 1Bα in Human and Mouse Shows EEF1B1 to Be a Recent Retrotransposition Event
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TLDR
This study illustrates the value of comparative mapping in distinguishing between processed pseudogenes and intronless paralogues.About:
This article is published in Genomics.The article was published on 2001-10-01. It has received 14 citations till now. The article focuses on the topics: Translation factor & Locus (genetics).read more
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Journal ArticleDOI
eEF1B: At the dawn of the 21st century.
Frédéric Le Sourd,Sandrine Boulben,Ronan Le Bouffant,Patrick Cormier,Julia Morales,Robert Bellé,Odile Mulner-Lorillon +6 more
TL;DR: The macromolecular complexity of eEF1B, its multiple phosphorylation sites and numerous cellular partners, lead us to suggest an essential role for the factor in the control of gene expression, particularly during the cell cycle.
Journal ArticleDOI
Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.
Dinesh C. Soares,Dinesh C. Soares,Paul N. Barlow,Helen J Newbery,David J. Porteous,Catherine M. Abbott +5 more
TL;DR: The revelation and putative functional assignment of two distinct sub-clusters on the surface of the protein models should enable rational site-directed mutagenesis, including homologous reverse-substitution experiments, to map surface binding patches onto these proteins.
Journal ArticleDOI
Translation factors: in sickness and in health
TL;DR: This work has discovered recently that mutations in subunits of eukaryotic initiation factor 2B (eIF2B) underlie the neurodegenerative disease termed 'vanishing white matter'.
Journal ArticleDOI
Effects of Emdogain on osteoblast gene expression.
Francesco Carinci,Adriano Piattelli,Luigi Guida,Perrotti,Gregorio Laino,Adriana Oliva,Marco Annunziata,Annalisa Palmieri,Furio Pezzetti +8 more
TL;DR: The data reported are the first genome-wide scan of the effect of enamel matrix proteins on osteoblast-like cells and can contribute to the understanding of the molecular mechanisms of bone regeneration and as a model for comparing other materials with similar clinical effects.
Journal ArticleDOI
Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2
TL;DR: It is shown that eEF1B subunits are all widely expressed to varying degrees in different cell lines and tissues, and at different stages of development, and that ablation of any of the subunits in human cell lines has a small but significant impact on cell viability and cycling.
References
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Journal ArticleDOI
Maps from two interspecific backcross DNA panels available as a community genetic mapping resource
Lucy B. Rowe,J. H. Nadeau,R. Turner,Wayne N. Frankel,Verity A. Letts,Janan Eppig,Minoru S.H. Ko,S. J. Thurston,Edward H. Birkenmeier +8 more
TL;DR: Large quantities of DNA from most tissues of each animal are prepared to create a community resource of interspecific backcross DNA for use by laboratories interested in mapping loci in the mouse.
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Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33–q35
Afif Hentati,Khemissa Bejaoui,Margaret A. Pericak-Vance,Fayçal Hentati,Marcy C. Speer,Wu Yen Hung,Denise A. Figlewicz,Jonathan L. Haines,Jackie B. Rimmler,Christiane Ben Hamida,Mongi Ben Hamida,Robert H. Brown,Teepu Siddique +12 more
TL;DR: To localize the gene for one of the autosomal recessive forms of ALS, linkage analysis to a large inbred family from Tunisia suggested that the ALS2 locus lies in the 8 cM segment flanked by D2S755 and D2 S775.
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The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene.
TL;DR: Data suggest that there are tissue-specific forms of the translation elongation apparatus essential for postnatal survival in the mouse, and takes over from Eef1a2 in heart and muscle at precisely the time at which the wasted phenotype becomes manifest.
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Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3.
TL;DR: The functional EEF1A gene is mapped to 6q14 by combined fluorescence in situ hybridization (FISH) and PCR analysis of a somatic cell hybrid panel and EF1A2 to 20q13.3 by FISH.