Journal ArticleDOI
Comparative stimulant and diuretic actions of caffeine and theobromine in man.
L. J. Dorfman,M. E. Jarvik +1 more
TLDR
Caffeine altered self‐estimates of sleep latency and sleep quality in a dose‐dependent fashion and increased overnight urinary sodium excretion and theobromine in equivalent doses had no detectable effect on sleep parameters or on urine composition.Abstract:
Human subiects ingested measured quantities of caffeine and theobromine, separately and together, at random. The double-blind technique was used. Caffeine altered self-estimates of sleep latency and sleep quality in a dose-dependent fashion and increased overnight urinary sodium excretion. Theobromine in equivalent doses had no detectable effect on sleep parameters or on urine composition, nor did it interact significantly with caffeine when the two were ingested together. Theobromine is much weaker than caffeine or entirely inert in these situations.read more
Citations
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Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
TL;DR: Caffeine is the most widely consumed central-nervous-system stimulant as discussed by the authors, however, its psychostimulant action on man is often subtle and not very easy to detect.
Journal ArticleDOI
Scientific Opinion on the safety of caffeine
TL;DR: The EFSA Panel on Dietetic Products, Nutrition and Allergies was asked to deliver a scientific opinion on the safety of caffeine, providing advice on caffeine intakes, considers that caffeine intakes of no concern derived for acute caffeine consumption by adults (3 mg/kg bw per day) may serve as a basis to derive single doses of caffeine and daily caffeine intakesof no concern for these population subgroups.
Journal ArticleDOI
Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals.
TL;DR: Caffeine/coffee stimulates the metabolic rate in both control and obese individuals; however, this is accompanied by greater oxidation of fat in normal weight subjects.
Journal ArticleDOI
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Benjamin Boutrel,George F. Koob +1 more
TL;DR: Understanding the exact role of the hypocretin/orexin and dopamine systems in the physiology and pharmacology of sleep-wake regulation may reveal new insights into current and future wakefulness-promoting drugs.
Journal ArticleDOI
Caffeine ingestion and fluid balance: a review
Ronald J. Maughan,J. Griffin +1 more
TL;DR: There would appear to be no clear basis for refraining from caffeine containing drinks in situations where fluid balance might be compromised and the most ecologically valid of the published studies offers no support for the suggestion that consumption of caffeine-containing beverages as part of a normal lifestyle leads to fluid loss in excess of the volume ingested or is associated with poor hydration status.
References
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Journal ArticleDOI
Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)
TL;DR: The evidence presented supports the hypothesis that the positive inotropic response to the catecholamines is mediated by cyclic AMP.
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A study of the metabolism of theobromine, theophylline, and caffeine in man.
TL;DR: The present investigation concerns the identification and quantitative determination of the methyluric acids and methylxanthines excreted in the urine of man after the ingestion of theobromine, theophylline, and caffeine.
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Psychotropic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee.
TL;DR: The users reacted positively to caffeine, reporting increased alertness, decreased irritability, and a feeling of contentedness, entirely consistent with those obtained by a questionnaire survey in the same and other women, reported in the preceding paper.
Journal ArticleDOI
The tolerance of coffee drinkers to caffeine
TL;DR: To decaffeinated coffee powder was added either caffeine or lactose, each in an amount of 150 mg per dose, which was significantly more effective than the lactose placebo at inducing a reduction in pulse rate in noncoffee drinkers, but not in those who habitually consumed caffeinated beverages.
Journal Article
Psychotropic effects of caffeine in man. i. individual differences in sensitivity to caffeine-induced wakefulness
TL;DR: Very large individual differences in the degree of wakefulness (delay of sleep onset) produced by caffeine were demonstrated unequivocally in a group of 20 subjects given caffeine (300 mg) or placebo before bedtime on 10 successive weeknights.