Journal ArticleDOI
Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics
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TLDR
High-resolution transmission electron microscopy observations confirmed that defects, in particular those involving grain boundaries, were the starting point of dissolution in vivo and may help to explain the mechanism by which silicate ions increase the in vivo bioactivity of pure HA.About:
This article is published in Biomaterials.The article was published on 2003-11-01. It has received 391 citations till now. The article focuses on the topics: Bioceramic.read more
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Shield effect of silicate on adsorption of proteins onto silicon-doped hydroxyapatite (100) surface.
TL;DR: It was found that the silicate ions on SiHA (100) surface cause a shield effect, which was composed of the charge repulsion and the steric hindrance of silicates, suggesting that surface engineering technologies can be potentially used to directly control/manufacture the nanoscale surface texture and the composition of material surfaces to mediate the interaction of proteins with biomaterials.
Journal ArticleDOI
Customized hydroxyapatites for bone-tissue engineering and drug delivery applications: a review
TL;DR: This review primarily focuses on highlighting the customization of desirable properties by controlling particles size, morphology, synthesis parameters, and substitution of mono/multi ions into HAP structure to obtain a product appropriate for bone-tissue engineering and drug delivery applications.
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Bone regeneration with hydroxyapatite-based biomaterials
TL;DR: Throughout CPCs, β-tricalcium phosphate (β-TCP), biphasic calcium phosphates (BCPs), and hydroxyapatite (HA) are frequently used in regeneration studies, and their resemblance to the inorganic part of bone makes them good alternatives to autografteds and allografts.
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Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep.
Laura Casarrubios,N. Gómez-Cerezo,Sandra Sánchez-Salcedo,María José Feito,María Concepción Serrano,M. Saiz-Pardo,L. Ortega,D. de Pablo,Idoia Díaz-Güemes,B. Fernández-Tomé,Silvia Enciso,Francisco M. Sánchez-Margallo,María Teresa Portolés,Daniel Arcos,María Vallet-Regí +14 more
TL;DR: For the first time, the in vivo behavior of scaffolds made of silicon substituted hydroxyapatites (SiHA) has been evaluated under osteoporosis conditions and shed light on the important issue of the biological response of nano-sized bioceramics vs highly crystalline biocerramics, as well as on the importance of coupling vascularization and bone growth processes by decorating SiHA scaffolds with vascular endothelial growth factor.
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Preparation and characterization of silicon-substituted hydroxyapatite coating by a biomimetic process on titanium substrate
TL;DR: A biomimetic method has been used to prepare silicon-substituted hydroxyapatite (Si-HA) coatings on titanium substrates by using X-ray diffraction, XPS, and Fourier transformed infrared spectroscopy (FTIR) as mentioned in this paper.
References
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Book
Theory of Dislocations
John Price Hirth,Jens Lothe +1 more
TL;DR: Dislocations in Isotropic Continua: Effects of Crystal Structure on Dislocations and Dislocation-Point-Defect Interactions at Finite temperatures.
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Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function
Paul Ducheyne,Qing-Qing Qiu +1 more
TL;DR: This review describes some of the current concepts regarding the surface reactivity of bone bioactive materials and its effect on attachment, proliferation, differentiation and mineralization of bone cells.
Journal ArticleDOI
Silicon: A Possible Factor in Bone Calcification
TL;DR: Silicon, a relatively unknown trace element in nutritional research, has been uniquely localized in active calcification sites in young bone and is suggested to be associated with calcium in an early stage of calcification.
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The effect of calcium phosphate ceramic composition and structure on in vitro behavior. II. Precipitation.
TL;DR: The dissolution behavior of the CPCs studied was found to vary over a wide range, and the dissolution rate of the monophase CPCs increased in the order of stoichiometric hydroxyapatite, calcium deficient hydroxyicarbonate, oxyhydroxyapatites, beta-tricalcium phosphate, alpha-tricals calcium phosphate, and tetracalcium phosphate.
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Chemical characterization of silicon-substituted hydroxyapatite.
TL;DR: Chemical analysis confirmed the proposed substitution of the silicon (or silicate) ion for the phosphorus (or phosphate) ion in hydroxyapatite and demonstrated that phase-pure silicon-substituted hydroxyAPatite may be prepared using a simple precipitation technique.