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Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics

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TLDR
High-resolution transmission electron microscopy observations confirmed that defects, in particular those involving grain boundaries, were the starting point of dissolution in vivo and may help to explain the mechanism by which silicate ions increase the in vivo bioactivity of pure HA.
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This article is published in Biomaterials.The article was published on 2003-11-01. It has received 391 citations till now. The article focuses on the topics: Bioceramic.

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Citations
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In vitro bioactivity and degradation of polycaprolactone composites containing silicate fillers.

TL;DR: Overall, the limited observed bioactivity of both composites within the test period may be related to the hydrophobicity of the matrix, insufficient ionic activity since SBF was not replenished and the relatively low content of the low surface areas fillers.
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Calcium Phosphates and Hydroxyapatite: Solid State NMR Experiments and First Principles Calculations

TL;DR: In this article, the projection augmented wave (PAW) and gauge including PAW methods allowed the complete assignment of spectra, including 1H magic-angle spinning (MAS) spectra for which ultimate resolution is not attained experimentally.
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Accurate characterization of pure silicon-substituted hydroxyapatite powders synthesized by a new precipitation route

TL;DR: The results, particularly those from infrared spectroscopy, raise serious reservations about the phase purity of previously prepared and biologically evaluated SiHA powders, pellets and scaffolds in the literature.
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Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

TL;DR: This review tries to give a brief and comprehensive introduction about HA-based materials, including ion-doped HA, HA/polymer composites and surface modified HA and their applications in bone tissue engineering.
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Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

TL;DR: The present review is mainly focused on both the capability of HAp nanoparticles to encapsulate diverse compounds as well as the preparation methods of scaffolds incorporating HAp.
References
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Book

Theory of Dislocations

TL;DR: Dislocations in Isotropic Continua: Effects of Crystal Structure on Dislocations and Dislocation-Point-Defect Interactions at Finite temperatures.
Journal ArticleDOI

Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function

TL;DR: This review describes some of the current concepts regarding the surface reactivity of bone bioactive materials and its effect on attachment, proliferation, differentiation and mineralization of bone cells.
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Silicon: A Possible Factor in Bone Calcification

TL;DR: Silicon, a relatively unknown trace element in nutritional research, has been uniquely localized in active calcification sites in young bone and is suggested to be associated with calcium in an early stage of calcification.
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The effect of calcium phosphate ceramic composition and structure on in vitro behavior. II. Precipitation.

TL;DR: The dissolution behavior of the CPCs studied was found to vary over a wide range, and the dissolution rate of the monophase CPCs increased in the order of stoichiometric hydroxyapatite, calcium deficient hydroxyicarbonate, oxyhydroxyapatites, beta-tricalcium phosphate, alpha-tricals calcium phosphate, and tetracalcium phosphate.
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Chemical characterization of silicon-substituted hydroxyapatite.

TL;DR: Chemical analysis confirmed the proposed substitution of the silicon (or silicate) ion for the phosphorus (or phosphate) ion in hydroxyapatite and demonstrated that phase-pure silicon-substituted hydroxyAPatite may be prepared using a simple precipitation technique.
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