Competing Risks Model in Early Screening for Preeclampsia by Biophysical and Biochemical Markers
TLDR
A new model has been developed for effective first-trimester screening for PE based on maternal characteristics, biophysical and biochemical markers based on a survival time model for the time of delivery in which Bayes’ theorem was used.Abstract:
Objective: To develop models for prediction of preeclampsia (PE) based on maternal characteristics, biophysical and biochemical markers at 11–13 weeks’ gestationread more
Citations
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Journal ArticleDOI
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
Daniel L. Rolnik,David Wright,Liona C. Poon,Neil O'Gorman,Argyro Syngelaki,Catalina De Paco Matallana,Ranjit Akolekar,Simona Cicero,D. Janga,Mandeep Singh,Francisca S. Molina,Nicola Persico,Nicola Persico,Jacques Jani,Walter Plasencia,G. Papaioannou,Kinneret Tenenbaum-Gavish,Hamutal Meiri,Sveinbjörn Gizurarson,Kate Maclagan,Kypros H. Nicolaides +20 more
TL;DR: Treatment with low‐dose aspirin in women at high risk for preterm preeclampsia resulted in a lower incidence of this diagnosis than placebo, and there were no significant between‐group differences in the incidence of neonatal adverse outcomes or other adverse events.
Journal ArticleDOI
The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention.
Liona C. Poon,Andrew Shennan,Jonathan A. Hyett,Anil Kapur,Eran Hadar,Hema Divakar,Fionnuala M. McAuliffe,Fabricio da Silva Costa,Peter von Dadelszen,Harold David McIntyre,A.B. Kihara,Gian Carlo Di Renzo,Roberto Romero,Mary E. D'Alton,Vincenzo Berghella,Kypros H. Nicolaides,Moshe Hod +16 more
TL;DR: The quest to effectively predict PE in the first trimester of pregnancy is fueled by the desire to identify women who are at high risk of developing PE, so that necessary measures can be initiated early enough to improve placentation and thus prevent or at least reduce the frequency of its occurrence.
Journal ArticleDOI
Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks gestation
Neil O'Gorman,David Wright,Argyro Syngelaki,Ranjit Akolekar,Alan Wright,Leona Poon,Kypros H. Nicolaides +6 more
TL;DR: Combination of maternal factors and biomarkers provides effective first-trimester screening for preterm-preeclampsia.
Journal ArticleDOI
Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy: Executive Summary
Laura A. Magee,Anouk Pels,Michael Helewa,Evelyne Rey,Peter von Dadelszen,François Audibert,Emmanuel Bujold,Anne-Marie Côté,Myrtle Joanne Douglas,Genevieve Eastabrook,Tabassum Firoz,Paul Gibson,Andrée Gruslin,Jennifer A. Hutcheon,Gideon Koren,Ian Lange,Line Leduc,Alexander G. Logan,Karen L. MacDonell,Jean-Marie Moutquin,Ilana Sebbag +20 more
TL;DR: The current evidence assessed in the clinical practice guideline prepared by the Canadian Hypertensive Disorders of Pregnancy Working Group and published by Pregnancy Hypertension to provide a reasonable approach to the diagnosis, evaluation, and treatment of the hypertensive disorders of pregnancy is presented.
Journal ArticleDOI
Competing risks model in screening for preeclampsia by maternal characteristics and medical history.
TL;DR: A new model that is based on maternal characteristics and medical history has been developed for the estimation of patient-specific risks for preeclampsia and is an essential first step in the use of Bayes theorem to combine maternal factors with biomarkers for the continuing development of more effective methods of screening for the disease.
References
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TL;DR: Although it is a low cost effective treatment, magnesium sulfate is not available in all low and middle income countries; scaling up its use for eClampsia and severe preeclampsia will contribute to achieving the Millennium Development Goals.
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A critical evaluation of sonar "crown-rump length" measurements.
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TL;DR: Evaluation of the reproducibility and accuracy of the sonar technique of measurement of the in vivo fetal crown‐rump length showed that the basic sonar measurements were in error by an overestimate of 1 mm for the beam width effect and 3.7 per cent for the scale factor and velocity calibration errors.
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