Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
Daniel L. Rolnik,David Wright,Liona C. Poon,Neil O'Gorman,Argyro Syngelaki,Catalina De Paco Matallana,Ranjit Akolekar,Simona Cicero,D. Janga,Mandeep Singh,Francisca S. Molina,Nicola Persico,Nicola Persico,Jacques Jani,Walter Plasencia,G. Papaioannou,Kinneret Tenenbaum-Gavish,Hamutal Meiri,Sveinbjörn Gizurarson,Kate Maclagan,Kypros H. Nicolaides +20 more
TLDR
Treatment with low‐dose aspirin in women at high risk for preterm preeclampsia resulted in a lower incidence of this diagnosis than placebo, and there were no significant between‐group differences in the incidence of neonatal adverse outcomes or other adverse events.Abstract:
BackgroundPreterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia. MethodsIn this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with singleton pregnancies who were at high risk for preterm preeclampsia to receive aspirin, at a dose of 150 mg per day, or placebo from 11 to 14 weeks of gestation until 36 weeks of gestation. The primary outcome was delivery with preeclampsia before 37 weeks of gestation. The analysis was performed according to the intention-to-treat principle. ResultsA total of 152 women withdrew consent during the trial, and 4 were lost to follow up, which left 798 participants in the aspirin group and 822 in the placebo group. Preterm preeclampsia occurred in 13 participants (1.6%) in the aspirin group, as compared with 35 (4.3%) in the placebo group (odds ratio in the aspirin group, 0.38; 95% confidenc...read more
Citations
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2018 ESC/ESH Guidelines for the management of arterial hypertension.
B. Williams,G. Mancia,Wilko Spiering,Agabiti Rosei E,M. Azizi,Michel Burnier,Denis Clement,A. Coca,de Simone G,A Dominiczak,T. Kahan,Felix Mahfoud,Josep Redon,L.M. Ruilope,Alberto Zanchetti,Mary Kerins,S.E. Kjeldsen,Reinhold Kreutz,S. Laurent,Lip Gyh.,Richard J McManus,Krzysztof Narkiewicz,Frank Ruschitzka,R.E. Schmieder,Evgeny Shlyakhto,Constantinos Tsioufis,Aboyans,Ileana Desormais +27 more
Journal ArticleDOI
2018 ESC/ESH Guidelines for the management of arterial hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension
Bryan Williams,Giuseppe Mancia,Wilko Spiering,Enrico Agabiti Rosei,Michel Azizi,Michel Burnier,Denis Clement,Antonio Coca,Giovanni de Simone,Anna F. Dominiczak,Thomas Kahan,Felix Mahfoud,Josep Redon,Luis M. Ruilope,Alberto Zanchetti,Mary Kerins,Sverre E. Kjeldsen,Reinhold Kreutz,Stéphane Laurent,Gregory Y.H. Lip,Richard J McManus,Krzysztof Narkiewicz,Frank Ruschitzka,Roland E. Schmieder,Evgeny Shlyakhto,Costas Tsioufis,Victor Aboyans,Ileana Desormais +27 more
TL;DR: De Backer et al. as mentioned in this paper developed the ESC Guidelines for the ESC Review Co-ordinator, which are used for the evaluation of the ESC review process and the review process.
Journal ArticleDOI
2020 International Society of Hypertension global hypertension practice guidelines
Thomas Unger,Claudio Borghi,Fadi J. Charchar,Fadi J. Charchar,Fadi J. Charchar,Nadia A. Khan,Neil Poulter,Dorairaj Prabhakaran,Dorairaj Prabhakaran,Agustin J. Ramirez,Markus P. Schlaich,Markus P. Schlaich,George S. Stergiou,Maciej Tomaszewski,Maciej Tomaszewski,Richard D Wainford,Bryan Williams,Aletta E. Schutte,Aletta E. Schutte,Aletta E. Schutte +19 more
TL;DR: Document reviewers: Hind Beheiry (Sudan), Irina Chazova (Russia), Albertino Damasceno (Mozambique), Anna Dominiczak (UK), Stephen Harrap (Australia), Hiroshi Itoh (Japan), Tazeen Jafar (Singapore), Marc Jaffe (USA), Patricio Jaramillo-Lopez (Colombia), Kazuomi Kario (Japan).
Journal ArticleDOI
[2018 ESC/ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH)].
Bryan Williams,Giuseppe Mancia,Wilko Spiering,Enrico Agabiti Rosei,Michel Azizi,Michel Burnier,Denis Clement,Antonio Coca,Giovanni de Simone,Anna F. Dominiczak,Thomas Kahan,Felix Mahfoud,Josep Redon,Luis M. Ruilope,Alberto Zanchetti,Mary Kerins,Sverre E. Kjeldsen,Reinhold Kreutz,Stéphane Laurent,Gregory Y.H. Lip,Richard J McManus,Krzysztof Narkiewicz,Frank Ruschitzka,Roland E. Schmieder,Evgeny Shlyakhto,Costas Tsioufis,Victor Aboyans,Ileana Desormais +27 more
TL;DR: Authors/Task Force Members: Bryan Williams* (ESC Chairperson), Giuseppe Mancia* (ESH Chairperson) (Italy), Wilko Spiering (The Netherlands), Enrico Agabiti Rosei ( Italy), Michel Azizi (France), Michel Burnier (Switzerland), Denis L. Kjeldsen (Norway), Reinhold Kreutz (Germany), Stephane Laurent (France)
Journal ArticleDOI
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Vera Regitz-Zagrosek,Jolien W. Roos-Hesselink,Johann Bauersachs,Carina Blomstrom-Lundqvist,Renata Cifkova,Michele De Bonis,Bernard Iung,Mark R. Johnson,Ulrich Kintscher,Peter Kranke,Irene Marthe Lang,João Morais,Petronella G. Pieper,Patrizia Presbitero,Susanna Price,Giuseppe M.C. Rosano,Ute Seeland,Tommaso Simoncini,Lorna Swan,Carole A Warnes +19 more
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