Journal ArticleDOI
Competitive antagonists of bradykinin
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TLDR
The first sequence-related competitive inhibitors of the classic kinin in vitro (rat uterus guinea pig ileum) and in vivo (rat blood pressure) assays have been developed.About:
This article is published in Peptides.The article was published on 1985-03-01. It has received 445 citations till now. The article focuses on the topics: Kallidin & Bradykinin B2 Receptor Antagonists.read more
Citations
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Journal ArticleDOI
International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences
L. M. Fredrik Leeb-Lundberg,François Marceau,Werner Müller-Esterl,Douglas J. Pettibone,Bruce L. Zuraw +4 more
TL;DR: This review is a comprehensive presentation of the current understanding of B1 and B2 receptors in terms of molecular and cell biology, physiology, pharmacology, and involvement in human disease and drug development.
Journal ArticleDOI
Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies
K. Wirth,F.J. Hock,Udo Dr Albus,Wolfgang Linz,H.G. Alpermann,H. Anagnostopoulos,St. Henke,G. Breipohl,W. König,J. Knolle,Bernward A. Schölkens +10 more
TL;DR: Hoe 140 has been shown to be a highly potent and long acting BK antagonist in vivo in different animal species and models and makes it appropriate to investigate further the physiological and pathophysiological role of BK.
Journal Article
The B1 Receptors for Kinins
TL;DR: A literature review on kinin pharmacology that appeared in this journal in 1980 was based on a systematic effort to define two receptor types for bradykinin- (BK b) related peptides, and proposed a receptor nomenclature (B1, B2).
Journal ArticleDOI
Bradykinin receptors: pharmacological properties and biological roles.
TL;DR: The emphasis in this review is to outline the current understanding of the properties of bradykinin receptors and the potential therapeutic applications for drugs acting at these sites.
Journal ArticleDOI
The kallikrein-kinin system: current and future pharmacological targets.
Marie Eve Moreau,Nancy Garbacki,Giuseppe Molinaro,Nancy J. Brown,François Marceau,Albert Adam +5 more
TL;DR: The main properties of this kallikrein-kinin system are summarized and the multiple pharmacological interventions that modulate the functions of this system, restraining its proinflammatory effects or potentiating its cardiovascular properties are addressed.
References
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Solid Phase Peptide Synthesis
TL;DR: This work has shown that effective methods of peptide synthesis are crucial to progress in this area, because only by synthesis can adequate amounts of important peptides be made available for chemical, biologi...
Journal ArticleDOI
Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin.
TL;DR: The stimulating principle disappeared from the blood very quickly after injection and could not be detected in samples taken a few minutes later, and no desensitization could be observed after several additions of the serum to the perfusing bath containing the piece of guinea pig ileum.