Journal ArticleDOI
Complexation behavior of PNIPAM-b-QPDMAEA copolymer aggregates with linear DNAs of different lengths
Despoina Giaouzi,Stergios Pispas +1 more
TLDR
In this paper, the authors investigated the complexation ability of CH3I quaternized HOOC-poly(N-isopropylacrylamide)-b-poly (2-(dimethylamino) acrylate)-C12H25 (HOOC-PNIPAM-b-QPDMAEA-C 12H25) thermoresponsive-cationic diblock copolymers, having different composition of the blocks, with linear DNA molecules of different lengths.About:
This article is published in European Polymer Journal.The article was published on 2021-07-15. It has received 4 citations till now. The article focuses on the topics: Lower critical solution temperature & Electrophoretic light scattering.read more
Citations
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Journal ArticleDOI
PnBA-b-PNIPAM-b-PDMAEA Thermo-Responsive Triblock Terpolymers and Their Quaternized Analogs as Gene and Drug Delivery Vectors.
TL;DR: In this paper, the ability of terpolymer self-assemblies with DNA to form polyplexes with DNA through electrostatic interactions was examined, and the structural characteristics of the polymers and the CUR-loaded aggregates were investigated by dynamic and electrophoretic light scattering techniques.
Journal ArticleDOI
Structure of micelleplexes formed between QPDMAEMA-b-PLMA amphiphilic cationic copolymer micelles and DNA of different lengths
TL;DR: In this paper , the structures of micelleplexes formed by quaternized poly(2-(dimethylamino) ethyl methacrylate)-b-poly(lauryl methacelate) (QPDMAEMA-b-PLMA) amphiphilic cationic copolymer micelles interacting electrostatically with linear DNA of different lengths (113 and 2000 base pairs).
Journal ArticleDOI
Aggregation behavior of triblock terpolymer poly[ n ‐butyl acrylate‐ block ‐ N ‐isopropylacrylamide‐ block ‐2‐(dimethylamino)ethyl acrylate] at the air/water interface
TL;DR: In this paper , a dual-responsive triblock terpolymer poly[n-butyl acrylate-block-N-isopropylacrylamide-block]-(2-(dimethylamino)ethyl acrylated] (PnBA-b-PNIPAM)-b-PDMAEA) was used to study the subphase pH and temperature effects on the aggregation behavior of a dualresponsive terpolymers at the air/water interface at the interface, and the results showed that the limiting areas in the surface pressure-molecular area isotherms under acidic and alkaline conditions are larger than that under neutral conditions.
Journal ArticleDOI
Fabrication and characterization of novel macroporous hydrogels based on the polymerizable surfactant AAc-Span80 and their enhanced drug-delivery capacity
Kai-Ming Tu,Junyan Wu,Weixia Zhu +2 more
TL;DR: In this article , a macroporous pH-sensitive poly[N-isopropylacrylamide-co-acrylic acid-sorbitan monooleate] hydrogels with an enhanced hydrophobic property and a rich pore structure were prepared by free-radical polymerization in an ethanol/water mixture.
References
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Journal ArticleDOI
Non-viral vectors for gene-based therapy
Hao Yin,Rosemary Lynn Kanasty,Ahmed A. Eltoukhy,Arturo J. Vegas,J. Robert Dorkin,Daniel G. Anderson +5 more
TL;DR: The biological barriers to gene delivery in vivo are introduced and recent advances in material sciences, nanotechnology and nucleic acid chemistry that have yielded promising non-viral delivery systems are discussed, some of which are currently undergoing testing in clinical trials.
Journal ArticleDOI
Progress and problems with the use of viral vectors for gene therapy
TL;DR: With the development of a leukaemia-like syndrome in two patients cured of a disease by gene therapy, it is timely to contemplate how far this technology has come, and how far it still has to go.
Journal ArticleDOI
Design and development of polymers for gene delivery
TL;DR: With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-Delivery systems will become an important tool for human gene therapy.
Journal ArticleDOI
Nonviral Vectors for Gene Delivery
TL;DR: Two nonviral gene delivery systems using either biodegradable poly(D,Llactide-co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells.
Journal ArticleDOI
Poly(ethylenimine) and its role in gene delivery
TL;DR: PEI chemistry and the characterization of PEI/DNA complexes used for gene delivery are reviewed and toxicity issues related to PEI transfection are surveyed.