Journal ArticleDOI
Composition and morphology of wear debris in failed uncemented total hip replacement
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Interfacial membranes collected at revision from 11 failed uncemented Ti-alloy total hip replacements were examined and polyethylene particles were found, similar to the particles seen in the base resin used in the manufacture of the acetabular implants.Abstract:
Interfacial membranes collected at revision from 11 failed uncemented Ti-alloy total hip replacements were examined. Particles in the membranes were characterised by electron microscopy, microchemical spectroscopy and particle size analysis. Most were polyethylene and had a mean size of 0.53 micron +/- 0.3. They were similar to the particles seen in the base resin used in the manufacture of the acetabular implants. Relatively few titanium particles were seen. Fragments of bone, stainless steel and silicate were found in small amounts. Most of the polyethylene particles were too small to be seen by light microscopy. Electron microscopy and spectroscopic techniques are required to provide an accurate description of this debris.read more
Citations
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Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine.
TL;DR: The diverse roles played by macrophages in these processes are discussed in addition to the potential manipulation of macrophage effector mechanisms as a strategy for promoting site-appropriate and constructive tissue remodeling as opposed to deleterious persistent inflammation and scar tissue formation.
Journal ArticleDOI
Biological reactions to wear debris in total joint replacement.
Eileen Ingham,John Fisher +1 more
TL;DR: It is concluded that the pre-clinical testing of any new materials for joint replacement must include an analysis of the wear particle characteristics and their biological reactivity in addition to the usual assessment of wear.
Journal ArticleDOI
The role of macrophages in osteolysis of total joint replacement.
Eileen Ingham,John Fisher +1 more
TL;DR: Evidence is provided that bone marrow-derived macrophages may play a dual role in osteolysis associated with total joint replacement, as the major cell in host defence responding to UHMWPE particles via the production of cytokines and secondly as precursors for the osteoclasts responsible for the ensuing bone resorption.
Journal ArticleDOI
Emergence of Nanoplastic in the Environment and Possible Impact on Human Health
TL;DR: The influence of particle size and surface chemistry are discussed, in order to understand the possible risks of nanoplastics for humans and provide recommendations for future studies.
Journal ArticleDOI
Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies
TL;DR: An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss.
References
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Journal ArticleDOI
The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis.
Steven R. Goldring,Alan L. Schiller,Merrilee S. Roelke,C M Rourke,D A O'Neil,William H. Harris +5 more
TL;DR: This transformation of tissue at the bone-cement interface in patients with a non-septic, loose total hip component to a synovial-like tissue with the capacity to generate prostaglandin E2 and collagenase may explain the progressive lysis of bone that is seen in some patients with loose cemented total joint implants.
Journal ArticleDOI
Reactions of the articular capsule to wear products of artificial joint prostheses.
H.-G. Willert,M. Semlitsch +1 more
TL;DR: Examination of a great number of tissue samples taken from the newly formed capsules surrounding artificial joints reveals small particles of prosthetic material, which initiate a foreign-body reaction and result in the formation of granulation tissue, including macrophages and foreign- body giant cells.
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Mechanism and clinical significance of wear debris-induced osteolysis
TL;DR: Wear debris induced osteolysis is discussed, which can potentially occur in any implant system regardless of implant design or fixation mode and should be a primary goal of orthopedic research in the future.
Journal ArticleDOI
Fluorometric quantification of DNA in cells and tissue.
TL;DR: This simple, one-step DNA extraction procedure can be utilized in conjunction with Hoechst reagent to obtain quantitative estimates of DNA levels in cell or tissue extracts to eliminate the need for enzyme treatment or exposure to high salt solutions.