Conformation-dependent Antibacterial Activity of the Naturally Occurring Human Peptide LL-37
Jan Johansson,Gudmundur H. Gudmundsson,Martin E. Rottenberg,Kurt D. Berndt,Birgitta Agerberth +4 more
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TLDR
A cooperative transition from disordered to helical structure is observed as the peptide concentration is increased, consistent with formation of an oligomer, and the extent of α-helicity correlates with the antibacterial activity of LL-37 against both Gram-positive and Gram-negative bacteria.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-02-06 and is currently open access. It has received 626 citations till now. The article focuses on the topics: Peptide & Circular dichroism.read more
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.
TL;DR: This review, which is focused on the different stages of membrane permeation induced by representatives of amphipathic alpha-helical antimicrobial and cell non-selective lytic peptides distinguishes between the 'carpet' mechanism, which holds for antimicrobial peptides versus the 'barrel-stave' mechanisms, which hold for cellnon- selective lytics peptides.
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Natively unfolded proteins: a point where biology waits for physics.
TL;DR: Results of this analysis showed that intrinsically unstructured proteins do not possess uniform structural properties, as expected for members of a single thermodynamic entity, and the Protein Quartet model, with function arising from four specific conformations (ordered forms, molten globule, premolten globules, and random coils) is discussed.
Journal ArticleDOI
Mode of action of membrane active antimicrobial peptides.
TL;DR: Although many studies support that bacterial membrane damage is a lethal event for bacteria, other studies point to a multihit mechanism in which the peptide binds to several targets in the cytoplasmic region of the bacteria.
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Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells
De Yang,Qian Chen,Albert P. Schmidt,G. Mark Anderson,Ji Ming Wang,Joseph Wooters,Joost J. Oppenheim,Oleg Chertov +7 more
TL;DR: The results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.
References
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Book
Proteins: Structures and Molecular Properties
TL;DR: This paper discusses the physical properties of polypeptides, the structure of which has been determined Crystallographically to High Resolution and its role in the biosynthesis of Proteins.
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Acetylornithinase of Escherichia coli: partial purification and some properties.
Henry J. Vogel,David M. Bonner +1 more
TL;DR: Compounds Used-N”l-Acetyl-n-ornithine was synthesized as previously described and L-Ornithine monohydrochloride was obtained from the Mann Research Laboratories.
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Computed circular dichroism spectra for the evaluation of protein conformation
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Peptide antibiotics and their role in innate immunity.
TL;DR: The results obtained imply that the polypeptide-like structure dominates in the structure derived from Polypeptides with S-S Bonds while in the case of Peptides Giving Mainly or Only fJ-Sheet Structures, the polymethine-rich structure is preferred.
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Solid phase synthesis
TL;DR: The purpose today is to describe the chemical synthesis of peptides and proteins and to discuss the use of the synthetic approach to answer various biological questions.