Journal ArticleDOI
Construction of recombinant FGFR1 containing full-length gene and its potential application.
TLDR
It is demonstrated that taspine can down-regulate phosphorylation of FGFR1 and ERK, and inhibit Hek293/FG FR1 and MCF-7 cell proliferation.About:
This article is published in Plasmid.The article was published on 2010-07-01. It has received 20 citations till now. The article focuses on the topics: Taspine & Cell growth.read more
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Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition
TL;DR: In this in-vitro study, it is found that puerarin inhibited the pro-apoptosis factor and upregulated the BDNF secret of astrocytes after OGD-R, indicating that the repairing effect of puerin was associated with theAstrocyte protection.
Journal ArticleDOI
Recent advances in cell membrane chromatography for traditional Chinese medicines analysis
Xiaofang Hou,Sicen Wang,Tao Zhang,Jing Ma,Jie Zhang,Yanmin Zhang,Wen Lu,Huaizhen He,Langchong He +8 more
TL;DR: Some of the latest progress and applications about CMC including instrument development, research on drug-receptor interactions, screening active components from TCMs, and quality control of TCMs are reviewed.
Journal ArticleDOI
TAS‐120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure
Maria Kalyukina,Yuliana Yosaatmadja,Martin Middleditch,Adam V. Patterson,Jeff B. Smaill,Christopher J. Squire +5 more
TL;DR: In this paper, the P-loop of the FGFR tyrosine kinase domain formed a covalent adduct with a cysteine side chain of the protein and the structural basis of this reactivity is revealed by a sequence of three X-ray crystal structures: a free ligand structure, a reversible FGFR1 structure, and the first reported irreversible FGFR 1 adduct structure.
Journal ArticleDOI
Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats.
TL;DR: IM showed antihypertensive and antioxidant effects in the renal injury of renovascular hypertensive rats, suggesting that IMP could be of therapeutic use in preventing renal injury related hypertension.
Journal ArticleDOI
Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway
TL;DR: Imperatorin showed antihypertensive effect via prevention of renal injury not only by reducing NADPH oxidase but also by inhibiting of MAPK pathway.
References
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Journal ArticleDOI
Fibroblast growth factor signalling: from development to cancer
Nicholas C. Turner,Richard Grose +1 more
TL;DR: There is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed.
Journal ArticleDOI
Cellular signaling by fibroblast growth factor receptors.
TL;DR: The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2,FGFR3 and FGFR4.
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Mechanisms underlying differential responses to FGF signaling.
TL;DR: A molecular picture is constructed of the different levels of regulation by which specific cellular responses could be achieved by FGF signals and focuses on the interaction with the Wnt pathway since FGF/Wnt cross-talk is emerging as an important nexus in regulating a variety of biological processes.
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Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction.
Journal ArticleDOI
Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer
Helen Davies,Christopher I. Hunter,Raffaella Smith,Philip J. Stephens,Christopher Greenman,Graham R. Bignell,Jon W. Teague,Adam Butler,Sarah Edkins,Claire Stevens,Adrian Parker,Sarah O’Meara,Tim Avis,Syd Barthorpe,Lisa Brackenbury,Gemma Buck,Jody Clements,Jennifer Cole,Ed Dicks,Ken Edwards,Simon A. Forbes,Matthew Gorton,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,David Jones,Vivienne Kosmidou,Ross Laman,Richard Lugg,Andrew Menzies,Janet Perry,Robert Petty,Keiran Raine,Rebecca Shepherd,Alexandra Small,Helen Solomon,Yvonne Stephens,Calli Tofts,Jennifer Varian,Anthony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Anthony R. Green,Maggie Knowles,Suet Yi Leung,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Tean Teh,Siu Tsan Yuen,Sunil R. Lakhani,Douglas F. Easton,Barbara L. Weber,Peter Goldstraw,Andrew G. Nicholson,Richard Wooster,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +64 more
TL;DR: The results suggest that several mutated protein kinases may be contributing to lung cancer development, but that mutations in each one are infrequent.