Journal ArticleDOI
Controlled-release matrix tablets of ibuprofen using cellulose ethers and carrageenans: effect of formulation factors on dissolution rates.
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TLDR
Most of the formulations released ibuprofen by an anomalous (non-Fickian) transport mechanism, except those matrices that contained methylcellulose and Gelcarin (in a 1:1 and 1:2 ratio), which showed zero-order release.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2005-09-01. It has received 131 citations till now. The article focuses on the topics: Controlled release & Polymer blend.read more
Citations
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Critical factors in the release of drugs from sustained release hydrophilic matrices
TL;DR: The most important factors to be taken into account when developing a formulation based on hydrophilic matrices are the percentage, solubility and drug particle size; the type of polymer, the percentage incorporated, its degree of viscosity and the polymer particle size.
Journal ArticleDOI
Carrageenan and its applications in drug delivery.
TL;DR: Based on the special characteristics of carrageenan, it has been used as a gelling agent/viscosity enhancing agent for controlled drug release and prolonged retention and for tissue regeneration with therapeutic biomacromolecules and for cell delivery.
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Polymeric Plant-derived Excipients in Drug Delivery
TL;DR: This review discusses some of the most important plant-derived polymeric compounds that are used or investigated as excipients in drug delivery systems.
Journal Article
Release of medroxyprogesterone acetate from a silicone polymer.
T. J. Roseman,William I. Higuchi +1 more
TL;DR: In this paper, the physicochemical factors involved in the in vitro release of medroxyprogesterone acetate (MPA) a water-insoluble steroid embedded in a silicone rubber matrix was based upon a model system which considered the matric boundary diffusion layer.
The role of oral controlled release matrix tablets in drug delivery systems.
TL;DR: The focus of this review is on matrix tablets due to their widely use and simplicity of the formulation and the mechanism of drug release from HPMC matrices.
References
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Journal ArticleDOI
A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
TL;DR: In this paper, an exponential relation M t /M ∞ = kt n may be used to describe the Fickian and non-Fickian release behavior of release systems which are prepared by incorporation of a drug in a hydrophilic, initially glassy polymer.
Journal ArticleDOI
Release of medroxyprogesterone acetate from a silicone polymer.
T. J. Roseman,William I. Higuchi +1 more
TL;DR: This study has suggested that the partition coefficient, diffusion coefficients, medroxyprogesterone acetate concentration within the polymer, and agitation conditions play important roles in the release process.
Journal Article
Release of medroxyprogesterone acetate from a silicone polymer.
T. J. Roseman,William I. Higuchi +1 more
TL;DR: In this paper, the physicochemical factors involved in the in vitro release of medroxyprogesterone acetate (MPA) a water-insoluble steroid embedded in a silicone rubber matrix was based upon a model system which considered the matric boundary diffusion layer.