Journal ArticleDOI
Release of medroxyprogesterone acetate from a silicone polymer.
T. J. Roseman,William I. Higuchi +1 more
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TLDR
This study has suggested that the partition coefficient, diffusion coefficients, medroxyprogesterone acetate concentration within the polymer, and agitation conditions play important roles in the release process.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1970-03-01. It has received 264 citations till now.read more
Citations
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A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
TL;DR: In this paper, a simple exponential relation Mt/M∞ = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt is the fractional release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.
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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
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On the importance and mechanisms of burst release in matrix-controlled drug delivery systems
Xiao Huang,Christopher S. Brazel +1 more
TL;DR: Experimental observations of burst release in monolithic polymer controlled drug delivery systems, theories of the physical mechanisms causing burst, some of the unique ideas used to prevent burst, and the treatment of burstRelease in controlled release models are reviewed.
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Higuchi equation: derivation, applications, use and misuse.
TL;DR: The aim of this review is to highlight the assumptions the derivation of the classical Higuchi equation is based on and to give an overview on the use and potential misuse of this equation as well as of related theories.
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Modeling of diffusion controlled drug delivery.
TL;DR: The aim of this article is to give an overview on the current state of the art of modeling drug release from delivery systems, which are predominantly controlled by diffusional mass transport.
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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Sustained release hormonal preparations. 2. Factors controlling the diffusion of steroids through dimethylpolysilozane membranes.
Kalyan Sundaram,Fred A. Kincl +1 more
TL;DR: Measurements of diffusion through porous glass discs, and of solubility in different solvents indicated that the steroid molecules diffuse through the dimethylpolysiloxane in a non-solvated form.
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Evaluation, Control, and Prediction of Drug Diffusion Through Polymeric Membranes III: Diffusion of Barbiturates, Phenylalkylamines, Dextromethorphan, Progesterone, and Other Drugs
TL;DR: The apparent diffusion constants through silastic membrane were determined by steady-state studies for a series of barbiturates and phenylalkylamines and correlated with the determined chloroform/acetate buffer partition coefficients in the former case.