Journal ArticleDOI
Controlled release of anticancer drug methotrexate from biodegradable gelatin microspheres
R Narayani,K P Rao +1 more
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TLDR
The in vitro release ofMTX was investigated in two different media, namely simulated gastric and intestinal fluids and the rate of release of MTX decreased with increase in the particle size of the microspheres, while MTX release was faster in gastric fluid when compared to intestinal fluid.Abstract:
Biodegradable hydrophilic gelatin microspheres containing the anticancer drug methotrexate (MTX) of different mean particle sizes (1-5, 5-10, and 15-20 microns) were prepared by polymer dispersion technique and crosslinked with glutaraldehyde. The microspheres were uniform, smooth, solid and in the form of free-flowing powder. About 80 per cent of MTX was incorporated in gelatin microspheres of different sizes. The in vitro release of MTX was investigated in two different media, namely simulated gastric and intestinal fluids. The release profiles indicated that gelatin microspheres released MTX in a zero-order fashion for 4-6 days in simulated gastric fluid and for 5-8 days in simulated intestinal fluid. The rate of release of MTX decreased with increase in the particle size of the microspheres. MTX release was faster in gastric fluid when compared to intestinal fluid.read more
Citations
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Biomedical applications of collagen
TL;DR: In this paper, the authors reviewed biomedical applications of collagen including the collagen film, which was developed as a matrix system for evaluation of tissue calcification and for the embedding of a single cell suspension for tumorigenic study.
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Polymer microspheres for controlled drug release
S. Freiberg,X. X. Zhu +1 more
TL;DR: This review presents the methods used in the preparation of microspheres from monomers or from linear polymers and discusses the physio-chemical properties that affect the formation, structure, and morphology of the spheres.
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Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells.
TL;DR: The intracellular trafficking model proposed was supported through nanoparticle uptake studies which demonstrated that cells expressing the human folate receptor internalized a higher level of nanoparticles than negative control cells.
Journal ArticleDOI
Glutaraldehyde as a fixative in bioprostheses and drug delivery matrices.
TL;DR: The chemistry of glutaraldehyde cross-linking and its effect on the biological performance of a number of bioprostheses such as tissue heart valves, vascular grafts, pericardial patches, tendon grafts and drug delivery matrices are examined.
Journal ArticleDOI
Methotrexate Conjugated to Gold Nanoparticles Inhibits Tumor Growth in a Syngeneic Lung Tumor Model
Yi Chen,Chiau Yuang Tsai,Pon Yu Huang,Meng Ya Chang,Pai Chiao Cheng,Chen Hsi Chou,Dong-Hwang Chen,Chrong-Reen Wang,Ai Li Shiau,Chao Liang Wu +9 more
TL;DR: By combining nanomaterials with anticancer drugs MTX-AuNP may be more effective than free MTX for cancer treatment, according to cytotoxic effect in vitro and antitumor effect in vivo.
References
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Journal ArticleDOI
New Approaches to Cancer Chemotherapy with Methotrexate
TL;DR: The prototypical folic acid antagonist, methotrexate, has been found effective in treating central giant cell granuloma and has shown antileukemic activity.
Journal ArticleDOI
Ionically cross-linkable polyphosphazene : a novel polymer for microencapsulation
TL;DR: In this paper, a solution aqueuse de poly(bis[carboxyphenoxy] phosphazene) entraine la formation d'un gel colloidal qui permet la microencapsulation de cellules, de liposomes ou de proteines.
Journal ArticleDOI
Release characteristics of cisplatin chitosan microspheres and effect of containing chitin.
Yutaka Nishioka,Shojiro Kyotani,Masashi Okamura,Masako Miyazaki,Kazuichi Okazaki,Saburo Ohnishi,Yasutake Yamamoto,Kenichi Ito +7 more
TL;DR: The results of this study showed that the CDDP content increased with increasing chitosan concentration and that the incorporation of chitin in the carrier matrix produced a more pronounced increase in drug content.
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Sustained pharmacological activities in rats following single and repeated administration of once-a-month injectable microspheres of leuprolide acetate.
TL;DR: The repeated injection of the microspheres at intervals of 2 or 4 weeks achieved persistent suppression of steroidogenesis after an initial transient flare-up and beneficially avoided the “acute-on-chronic response.”
Journal ArticleDOI
Preparation of controlled release anticancer agents I: 5-fluorouracil-ethyl cellulose microspheres
TL;DR: The drug release study from an aqueous gel base preparation at pH 7.0 through a synthetic membrane was found to be promising for formulation of a gel-microsphere product for the treatment of skin lesions.