Journal ArticleDOI
Controlling of systemic absorption of gliclazide through incorporation into alginate beads.
TLDR
The results clearly demonstrated the ability of the system to maintain tight blood glucose level and improved the patient compliance by enhancing, controlling and prolonging the systemic absorption of gliclazide.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2007-08-16. It has received 128 citations till now. The article focuses on the topics: Gliclazide & Intestinal absorption.read more
Citations
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Journal ArticleDOI
Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology.
Amit Kumar Nayak,Dilipkumar Pal +1 more
TL;DR: The newly developed TSP-alginate composite beads are suitable for controlled delivery of diclofenac sodium for prolonged period and their observed responses were coincided well with the predicted values by the experimental design.
Journal ArticleDOI
Sequential growth factor delivery from complexed microspheres for bone tissue engineering
TL;DR: Alkaline phosphatase activities were found to be lowest and cell proliferation was highest at all time points with foams carrying both the microsphere populations, regardless of BMP presence, with the present doses used.
Journal ArticleDOI
Fenugreek seed mucilage-alginate mucoadhesive beads of metformin HCl: Design, optimization and evaluation.
TL;DR: The optimized FSM-alginate mucoadhesive beads containing metformin HCl showed significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
Journal ArticleDOI
Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery: in vitro-in vivo evaluation.
Dilipkumar Pal,Amit Kumar Nayak +1 more
TL;DR: The in vivo studies on alloxan-induced diabetic rats demonstrated the significant hypoglycemic effect of selected formulation of TSP-alginate mucoadhesive microspheres containing gliclazide on oral administration, which may be very much useful for prolonged systemic absorption of glic lazide for proper maintaining blood glucose level and advanced patient compliance.
A review on ionotropic gelation method: novel approach for controlled gastroretentive gelispheres
TL;DR: The purpose of this review is to compile the recent literature with special focus on the method of preparation i.e. Ionotropic gelation method to achieve a pharmaceutical product with desired characteristics.
References
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Journal ArticleDOI
Protein release from alginate matrices.
Wayne R. Gombotz,Siow Fong Wee +1 more
TL;DR: By selection of the type of alginate and coating agent, the pore size, degradation rate, and ultimately release kinetics can be controlled.
Journal ArticleDOI
Alginate in drug delivery systems.
TL;DR: The present use and future possibilities of alginate as a tool in drug formulation are discussed, with the potential use of the various qualities as pharmaceutical excipients likely to make an important contribution in the development of polymeric delivery systems.
Journal ArticleDOI
Alginate as immobilization material: I. Correlation between chemical and physical properties of alginate gel beads
TL;DR: Beads with the highest mechanical strength, lowest shrinkage, best stability towards monovalent cations, and highest porosity were made from alginate with a content of L‐guluronic acid higher than 70% and an average length of the G‐blocks higher than 15.4 × 105.
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Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology.
Amit Kumar Nayak,Dilipkumar Pal +1 more