Journal ArticleDOI
Copper- and iron-catalyzed decarboxylative tri- and difluoromethylation of α,β-unsaturated carboxylic acids with CF3SO2Na and (CF2HSO2)2Zn via a radical process.
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TLDR
A copper-catalyzed decarboxylative trifluoromethylation of various α,β-unsaturated carboxylic acids by using a stable and inexpensive solid, sodium trif LUM, Langlois reagent, was developed.About:
This article is published in Organic Letters.The article was published on 2013-01-10. It has received 245 citations till now. The article focuses on the topics: Sodium trifluoromethanesulfinate & Trifluoromethylation.read more
Citations
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Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis
Chuanfa Ni,Mingyou Hu,Jinbo Hu +2 more
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Trifluoromethyltrimethylsilane: nucleophilic trifluoromethylation and beyond.
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Carbon trifluoromethylation reactions of hydrocarbon derivatives and heteroarenes.
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Radicals: Reactive Intermediates with Translational Potential
TL;DR: This Perspective illustrates the defining characteristics of free radical chemistry, beginning with its rich and storied history, and studies from the laboratory are discussed along with recent developments emanating from others in this burgeoning area.
References
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Journal ArticleDOI
Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
Journal ArticleDOI
Fluorine in medicinal chemistry.
TL;DR: This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
Journal ArticleDOI
Catalysis for fluorination and trifluoromethylation
TL;DR: Reactions to make organofluorides that have emerged within the past few years are discussed and which exemplify how to overcome some of the intricate challenges associated with fluorination.
Journal ArticleDOI
Aromatic Trifluoromethylation with Metal Complexes
TL;DR: Molecules bearing a trifluoromethyl group constitute one of the most important classes of selectively fluorinated compounds, and derivatives bearing the CF3 group on aromatic rings are particularly numerous and important.
BookDOI
Fluorine in medicinal chemistry and chemical biology
TL;DR: This book discusses applications of fluorinated amino acids and peptides to chemical biology and pharmacology, and recent Advances in the Syntheses of Fluorinated Amino Acids.