Journal ArticleDOI
Copper-Catalyzed Aerobic Oxidative C ? H Functionalizations: Trends and Mechanistic Insights
TLDR
This work has reported several recently reported Cu-catalyzed C-H oxidation reactions that feature substrates that are electron-deficient or appear unlikely to undergo single-electron transfer to copper(II), and evidence has been obtained for the involvement of organocopper(III) intermediates in the reaction mechanism.Abstract:
The selective oxidation of C-H bonds and the use of O(2) as a stoichiometric oxidant represent two prominent challenges in organic chemistry. Copper(II) is a versatile oxidant, capable of promoting a wide range of oxidative coupling reactions initiated by single-electron transfer (SET) from electron-rich organic molecules. Many of these reactions can be rendered catalytic in Cu by employing molecular oxygen as a stoichiometric oxidant to regenerate the active copper(II) catalyst. Meanwhile, numerous other recently reported Cu-catalyzed C-H oxidation reactions feature substrates that are electron-deficient or appear unlikely to undergo single-electron transfer to copper(II). In some of these cases, evidence has been obtained for the involvement of organocopper(III) intermediates in the reaction mechanism. Organometallic C-H oxidation reactions of this type represent important new opportunities for the field of Cu-catalyzed aerobic oxidations.read more
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An overview on the progress and development on metals/non-metal catalyzed cyanation reactions
Tayyaba Najam,Syed Shoaib Ahmad Shah,Khalid Mehmood,Ahmad Ud Din,Sabeena Rizwan,Muhammad Ashfaq,Salma Shaheen,Amir Waseem +7 more
TL;DR: In this paper, a review of recent developments on cyanation reactions for the synthesis of nitriles (RCN) through transition metal mediated cyanation reaction as well as by using non-metal like iodine (transition metal free system).
Journal ArticleDOI
Magnesium iodide-catalyzed synthesis of 2-substituted quinazolines using molecular oxygen and visible light
TL;DR: In this paper, a novel and efficient approach for the synthesis of quinazolines by aerobic photooxidation with an iodine reagent at room temperature is reported, using harmless visible light from compact fluorescent lamps and molecular oxygen as the sole oxidant without the need for a transition-metal catalyst or harsh reaction conditions.
Journal ArticleDOI
Copper(II) Acetate‐Catalyzed Hydroxysulfenylation‐Initiated Lactonization of Unsaturated Carboxylic Acids with Oxygen as Oxidant and Oxygenation Reagent
TL;DR: In this paper, a copper(II) acetate-catalyzed aerobic thiolation of C=C double bonds, oxygenation, and intramolecular cyclization reactions of unsaturated carboxylic acids with thiols has been explored.
Journal ArticleDOI
Cu-Catalyzed Cross-Dehydrogenative Coupling of Heteroaryl C(sp2)–H and Tertiary C(sp3)–H Bonds for the Construction of All-Carbon Triaryl Quaternary Centers
Zhi Tang,Zhili Liu,Tong Zhou,Xu Zhihui,Chak-Tong Au,Chak-Tong Au,Renhua Qiu,Nobuaki Kambe,Nobuaki Kambe +8 more
TL;DR: A Cu-catalyzed protocol for cross-dehydrogenative coupling of benzofuranones with quinolines, indoles, carbazoles, and thiophene, which furnishes highly functionalized 3,3-diaryl benz ofuranones bearing a three aryl quaternary carbon center at the C3 position in good yields, has been developed.
Journal ArticleDOI
Cu(II)-Catalyzed Oxidative Formation of 5,5′-Bistriazoles
Christopher J. Brassard,Xiaoguang Zhang,Christopher R. Brewer,Peiye Liu,Ronald J. Clark,Lei Zhu +5 more
TL;DR: Aromatic azide-derived 5,5'-bistriazoles possess rigid axially chiral structures with a broad distribution of dihedral angles, which may be explored as chiral ligands in enantioselective catalysis if decorated with proper functional groups.
References
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Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.
TL;DR: A review of palladium-catalyzed coupling of CH bonds with organometallic reagents through a PdII/Pd0 catalytic cycle can be found in this paper.
Journal ArticleDOI
Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds
Charles S. Yeung,Vy M. Dong +1 more
Journal ArticleDOI
Multicopper Oxidases and Oxygenases
TL;DR: Copper sites have historically been divided into three classes based on their spectroscopic features, which reflect the geometric and electronic structure of the active site: type 1 or blue copper, type 2 (T2) or normal copper, and type 3 (T3) or coupled binuclear copper centers.
Journal ArticleDOI
Rhodium-Catalyzed C-C Bond Formation via Heteroatom-Directed C-H Bond Activation
TL;DR: This review focuses on Rh-catalyzed methods for C-H bond functionalization, which have seen widespread success over the course of the last decade and are discussed in detail in the accompanying articles in this special issue of Chemical Reviews.
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