Journal ArticleDOI
Copper-Catalyzed Aerobic Oxidative C ? H Functionalizations: Trends and Mechanistic Insights
TLDR
This work has reported several recently reported Cu-catalyzed C-H oxidation reactions that feature substrates that are electron-deficient or appear unlikely to undergo single-electron transfer to copper(II), and evidence has been obtained for the involvement of organocopper(III) intermediates in the reaction mechanism.Abstract:
The selective oxidation of C-H bonds and the use of O(2) as a stoichiometric oxidant represent two prominent challenges in organic chemistry. Copper(II) is a versatile oxidant, capable of promoting a wide range of oxidative coupling reactions initiated by single-electron transfer (SET) from electron-rich organic molecules. Many of these reactions can be rendered catalytic in Cu by employing molecular oxygen as a stoichiometric oxidant to regenerate the active copper(II) catalyst. Meanwhile, numerous other recently reported Cu-catalyzed C-H oxidation reactions feature substrates that are electron-deficient or appear unlikely to undergo single-electron transfer to copper(II). In some of these cases, evidence has been obtained for the involvement of organocopper(III) intermediates in the reaction mechanism. Organometallic C-H oxidation reactions of this type represent important new opportunities for the field of Cu-catalyzed aerobic oxidations.read more
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Cobalt(III)‐katalysierte dirigierte C‐H‐Kupplung mit Diazoverbindungen: einfacher Zugang zu ausgedehnten π‐Systemen
TL;DR: In this paper, the erste hocheffiziente and skalierbare Cobalt-katalysierte dirigierte C-H-Funktionalisierung with Carbenvorstufen wird vorgestellt.
Journal ArticleDOI
Copper mediated decarboxylative direct C–H arylation of heteroarenes with benzoic acids
TL;DR: An economic and sustainable approach by using a simple copper salt was developed in the presence of molecular oxygen as the sole oxidant for decarboxylative coupling reactions.
Journal ArticleDOI
Direct silylation reactions of inert C-H bonds via transition metal catalysis
Yunhui Yang,Congyang Wang +1 more
TL;DR: In this article, the silylation reactions of inert C-H bonds catalyzed by transition metal complexes of Ir, Rh, Ru, Pt, Pd, Ni, and Sc have been summarized.
Journal ArticleDOI
A Biomimetic Catalytic Aerobic Functionalization of Phenols
TL;DR: This work reports a biomimetic approach that converts phenolic C-H bonds into C-O, C-N, and C-S bonds at the sole expense of reducing dioxygen (O2) to water (H2O).
Journal ArticleDOI
Mechanism and Origins of Selectivities in the Copper-Catalyzed Dearomatization-Induced ortho C–H Cyanation of Vinylarenes
Yang Yang,Yang Yang,Peng Liu +2 more
TL;DR: In this article, the copper-catalyzed regioselective ortho C-H cyanation of vinylarenes has been investigated using density functional theory calculations, which is composed of two discrete catalytic cycles.
References
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Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.
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Journal ArticleDOI
Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds
Charles S. Yeung,Vy M. Dong +1 more
Journal ArticleDOI
Multicopper Oxidases and Oxygenases
TL;DR: Copper sites have historically been divided into three classes based on their spectroscopic features, which reflect the geometric and electronic structure of the active site: type 1 or blue copper, type 2 (T2) or normal copper, and type 3 (T3) or coupled binuclear copper centers.
Journal ArticleDOI
Rhodium-Catalyzed C-C Bond Formation via Heteroatom-Directed C-H Bond Activation
TL;DR: This review focuses on Rh-catalyzed methods for C-H bond functionalization, which have seen widespread success over the course of the last decade and are discussed in detail in the accompanying articles in this special issue of Chemical Reviews.
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