Journal ArticleDOI
Core-Satellite Polydopamine-Gadolinium-Metallofullerene Nanotheranostics for Multimodal Imaging Guided Combination Cancer Therapy.
Sheng Wang,Sheng Wang,Jing Lin,Zhantong Wang,Zijian Zhou,Ruiliang Bai,Nan Lu,Yijing Liu,Xiao Fu,Orit Jacobson,Wenpei Fan,Junle Qu,Siping Chen,Tianfu Wang,Peng Huang,Xiaoyuan Chen +15 more
TLDR
The as‐prepared CDPGM NPs show good biocompatibility, strong NIR absorption, high relaxivity, low risk of release of Gd ions, and NIR‐triggered drug release, and suggest that the CDP GM NPs hold great promise for cancer theranostics.Abstract:
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-64 Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy. In this system, the near-infrared (NIR)-absorbing PDA acts as a platform for the assembly of different moieties; Gd3 N@C80 , a kind of gadolinium metallofullerene with three Gd ions in one carbon cage, acts as a satellite anchoring on the surface of PDA. The as-prepared CDPGM NPs show good biocompatibility, strong NIR absorption, high relaxivity (r 1 = 14.06 mM-1 s-1 ), low risk of release of Gd ions, and NIR-triggered drug release. In vivo MR/PA/PET multimodal imaging confirms effective tumor accumulation of the CDPGM NPs. Moreover, upon NIR laser irradiation, the tumor is completely eliminated with combined chemo-photothermal therapy. These results suggest that the CDPGM NPs hold great promise for cancer theranostics.read more
Citations
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Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
TL;DR: It is believed that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve the ability to combat cancers.
Journal ArticleDOI
Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine
TL;DR: In this review, recent significant research developments of PDA including its synthesis and polymerization mechanism, physicochemical properties, different nano/micro-structures and diverse applications are summarized and discussed.
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Near-Infrared-Light-Activatable Nanomaterial-Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment.
Raviraj Vankayala,Kuo Chu Hwang +1 more
TL;DR: Near‐infrared (NIR) light‐activated nanomaterial‐mediated phototherapies, including photothermal and photodynamic therapies, provide an alternative means for spatially and temporally controlled minimally invasive treatments of cancers.
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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics.
TL;DR: This review has summarized the general strategies of developing stimuli-responsive nanocarriers and recent advances, presented their applications in drug delivery, tumor imaging, therapy and theranostics, illustrated the progress of clinical translation and made prospects.
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Carbon-based nanomaterials as an emerging platform for theranostics
TL;DR: Carbon-based nanomaterials emerge as promising platforms for theranostic applications in disease treatment and tissue repair.
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