Journal ArticleDOI
Correlation between lipoprotein(a) and aortic valve sclerosis assessed by echocardiography (the JMS Cardiac Echo and Cohort Study)
Tadao Gotoh,Toshio Kuroda,Masanori Yamasawa,Masanori Nishinaga,Takeshi Mitsuhashi,Yoshitane Seino,Naoki Nagoh,Kazunori Kayaba,Seishi Yamada,Hitoshi Matsuo,Masahiko Hosoe,Yoshihisa Itoh,Tadashi Kawai,Masahiro Igarashi,Kazuyuki Shimada +14 more
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TLDR
Increased serum levels of Lp(a), as well as aging, are closely related to AV sclerosis, and there were no significant differences in the prevalence of AV sclerosis in terms of sex, blood pressure, or levels of total cholesterol, high-density lipoprotein cholesterol, triglycerides, or blood sugar.Abstract:
An elevated serum level of lipoprotein(a) (Lp[a]) may be an independent risk factor for atherosclerotic disease, but the relation of Lp(a) to aortic valve (AV) sclerosis has not been determined. We measured serum concentrations of Lp(a) and investigated their relation to the presence of echocardiographic AV sclerosis in residents of a rural village in Japan. We measured serum Lp(a) levels in 347 men ana 437 women aged 35 to 90 years (mean ± SD: 62 ± 11 years) who participated in mass screening examinations in Wara village, Gifu, Japan. AV sclerosis was assessed by longand short-axis 2-dimensional echocardiographic views and continuous-wave Doppler echocardiography. AV sclerosis was graded as follows: 0 = normal AV; 1 = increased echo density; 2 = thickening or calcific deposits ≥3 mm; and 3 = same as 2 with mildly restricted motion (pressure gradientread more
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Journal ArticleDOI
Clinical Factors Associated With Calcific Aortic Valve Disease
B. Fendley Stewart,David S. Siscovick,Bonnie K. Lind,Julius M. Gardin,John S. Gottdiener,Vivienne E. Smith,Dalane W. Kitzman,Catherine M Otto,Catherine M Otto +8 more
TL;DR: In this article, the prevalence of aortic sclerosis and stenosis in the elderly and to identify clinical factors associated with degenerative aortric valve disease were determined using stepwise logistic regression analysis.
Journal ArticleDOI
Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly.
Catherine M Otto,Bonnie K. Lind,Dalane W. Kitzman,Dalane W. Kitzman,Bernard J. Gersh,David S. Siscovick +5 more
TL;DR: There was a stepwise increase in deaths from any cause and deaths from cardiovascular causes with increasing aortic-valve abnormality with increasing the risk of cardiovascular events.
Journal ArticleDOI
Prospective Study of Asymptomatic Valvular Aortic Stenosis Clinical, Echocardiographic, and Exercise Predictors of Outcome
Catherine M Otto,Ian G. Burwash,Malcolm E. Legget,Brad Munt,Michelle Fujioka,Nancy L. Healy,Carol D. Kraft,Carolyn Y. Miyake-Hull,Rebecca Gibbons Schwaegler +8 more
TL;DR: In adults with asymptomatic AS, the rate of hemodynamic progression and clinical outcome are predicted by jet velocity, the rates of change inJet velocity, and functional status.
Journal ArticleDOI
Genetic associations with valvular calcification and aortic stenosis.
George Thanassoulis,George Thanassoulis,Catherine Y. Campbell,David S. Owens,J. Gustav Smith,J. Gustav Smith,Albert V. Smith,Gina M. Peloso,Gina M. Peloso,Kathleen F. Kerr,Sonali Pechlivanis,Matthew J. Budoff,Tamara B. Harris,Rajeev Malhotra,Kevin D. O'Brien,Pia R. Kamstrup,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Matthew A. Allison,Thor Aspelund,Michael H. Criqui,Susan R. Heckbert,Shih-Jen Hwang,Yongmei Liu,Marketa Sjögren,Jesper van der Pals,Hagen Kälsch,Thomas W. Mühleisen,Markus M. Nöthen,L. Adrienne Cupples,L. Adrienne Cupples,Muriel J. Caslake,Emanuele Di Angelantonio,John Danesh,Jerome I. Rotter,Sigurdur Sigurdsson,Quenna Wong,Raimund Erbel,Sekar Kathiresan,Sekar Kathiresan,Olle Melander,Vilmundur Gudnason,Christopher J. O'Donnell,Christopher J. O'Donnell,Wendy S. Post +44 more
TL;DR: Genetic variation in the LPA locus, mediated by Lp(a) levels, is associated with aortic-valve calcification across multiple ethnic groups and with incident clinical aorti stenosis.
Journal ArticleDOI
Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population.
TL;DR: Elevated Lp(a) levels and corresponding genotypes were associated with increased risk of AVS in the general population, with levels >90 mg/dl predicting a threefold increased risk.
References
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cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
John W. McLean,James E. Tomlinson,Wun-Jing Kuang,Dan L. Eaton,Ellson Y. Chen,Gunther M. Fless,Angelo M. Scanu,Richard M. Lawn +7 more
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Prevalence of aortic valve abnormalities in the elderly: An echocardiographic study of a random population sample☆
TL;DR: Calcific aortic valve stenosis constitutes a significant health problem in the elderly and only a minority of those with potentially operable aorta stenosis undergo surgery.
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Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography.
TL;DR: Plasma Lp(a) in white patients appears to be a major coronary risk factor with an importance approaching that of the level of LDL or HDL cholesterol.
Journal ArticleDOI
Lipoprotein Lp(a) and the risk for myocardial infarction
TL;DR: It is concluded that Lp(a) represents an independent addi tional risk factor for MI with a possible threshold value of approx.