M
Muriel J. Caslake
Researcher at University of Glasgow
Publications - 165
Citations - 14834
Muriel J. Caslake is an academic researcher from University of Glasgow. The author has contributed to research in topics: Lipoprotein & Very low-density lipoprotein. The author has an hindex of 63, co-authored 165 publications receiving 13806 citations. Previous affiliations of Muriel J. Caslake include Glasgow Royal Infirmary & University Hospitals of Morecambe Bay NHS Foundation Trust.
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Journal ArticleDOI
C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction
Stephen Kaptoge,Emanuele Di Angelantonio,Lisa Pennells,Angela M. Wood,Ian R. White,Pei Gao,Matthew G. Walker,Alexander M. W. Cargill Thompson,Nadeem Sarwar,Muriel J. Caslake,Adam S. Butterworth,Philippe Amouyel,Gerd Assmann,Stephan J. L. Bakker,Elizabeth L M Barr,Elizabeth Barrett-Connor,Emelia J. Benjamin,Cecilia Björkelund,Hermann Brenner,Eric J. Brunner,Robert Clarke,Jackie A. Cooper,Peter Cremer,Mary Cushman,Gilles R. Dagenais,Ralph B. D'Agostino,Rachel Dankner,George Davey-Smith,Dorly J. H. Deeg,Jacqueline M. Dekker,Gunnar Engström,Aaron R. Folsom,F. Gerry R. Fowkes,John Gallacher,J. Michael Gaziano,Simona Giampaoli,Richard F. Gillum,Albert Hofman,Barbara V. Howard,Erik Ingelsson,Hiroyasu Iso,Torben Jørgensen,Stefan Kiechl,Akihiko Kitamura,Yutaka Kiyohara,Wolfgang Koenig,Daan Kromhout,Lewis H. Kuller,Debbie A Lawlor,Tom W. Meade,Aulikki Nissinen,Børge G. Nordestgaard,Altan Onat,Demosthenes B. Panagiotakos,Bruce M. Psaty,Beatriz L. Rodriguez,Annika Rosengren,Veikko Salomaa,Jussi Kauhanen,Jukka T. Salonen,Jonathan A. Shaffer,Steven Shea,Ian Ford,Coen D.A. Stehouwer,Timo E. Strandberg,Robert W. Tipping,Alberto Tosetto,Sylvia Wassertheil-Smoller,Patrik Wennberg,Rudi G. J. Westendorp,Peter H. Whincup,Lars Wilhelmsen,Mark Woodward,Gordon D.O. Lowe,Nicholas J. Wareham,Kay-Tee Khaw,Naveed Sattar,Chris J. Packard,Vilmundur Gudnason,Paul M. Ridker,Mark B. Pepys,Simon G. Thompson,John Danesh +82 more
TL;DR: It is estimated that under current treatment guidelines, assessment of the CRP or fibrinogen level in people at intermediate risk for a cardiovascular event could help prevent one additional event over a period of 10 years for every 400 to 500 people screened.
Journal ArticleDOI
Lipoprotein-Associated Phospholipase A2 as an Independent Predictor of Coronary Heart Disease
Christopher J. Packard,Denis St. J. O’Reilly,Muriel J. Caslake,Alex D. McMahon,Ian Ford,Josephine Cooney,Colin H. Macphee,Keith E. Suckling,Mala Krishna,Francis E. Wilkinson,Ann Rumley,Gordon D.O. Lowe +11 more
TL;DR: Elevated levels of lipoprotein-associated phospholipase A2 appear to be a strong risk factor for coronary heart disease, a finding that has implications for atherogenesis and the assessment of risk.
Journal ArticleDOI
Genetic associations with valvular calcification and aortic stenosis.
George Thanassoulis,George Thanassoulis,Catherine Y. Campbell,David S. Owens,J. Gustav Smith,J. Gustav Smith,Albert V. Smith,Gina M. Peloso,Gina M. Peloso,Kathleen F. Kerr,Sonali Pechlivanis,Matthew J. Budoff,Tamara B. Harris,Rajeev Malhotra,Kevin D. O'Brien,Pia R. Kamstrup,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Matthew A. Allison,Thor Aspelund,Michael H. Criqui,Susan R. Heckbert,Shih-Jen Hwang,Yongmei Liu,Marketa Sjögren,Jesper van der Pals,Hagen Kälsch,Thomas W. Mühleisen,Markus M. Nöthen,L. Adrienne Cupples,L. Adrienne Cupples,Muriel J. Caslake,Emanuele Di Angelantonio,John Danesh,Jerome I. Rotter,Sigurdur Sigurdsson,Quenna Wong,Raimund Erbel,Sekar Kathiresan,Sekar Kathiresan,Olle Melander,Vilmundur Gudnason,Christopher J. O'Donnell,Christopher J. O'Donnell,Wendy S. Post +44 more
TL;DR: Genetic variation in the LPA locus, mediated by Lp(a) levels, is associated with aortic-valve calcification across multiple ethnic groups and with incident clinical aorti stenosis.
Journal ArticleDOI
C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study
Dilys J. Freeman,John Norrie,Muriel J. Caslake,Allan Gaw,Ian Ford,Gordon D.O. Lowe,Denis St. J. O’Reilly,Chris J. Packard,Naveed Sattar +8 more
TL;DR: Observations about C-reactive protein add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes, and have clinical potential in helping to better predict individuals destined to develop type 1 diabetes.
Journal ArticleDOI
Overproduction of large VLDL particles is driven by increased liver fat content in man.
Martin Adiels,Marja-Riitta Taskinen,Chris J. Packard,Muriel J. Caslake,Aino Soro-Paavonen,Jukka Westerbacka,Satu Vehkavaara,Anna-Maija Häkkinen,Sven-Olof Olofsson,Hannele Yki-Järvinen,Jan Borén,Jan Borén +11 more
TL;DR: It is proposed that the metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, increases fatty acid flux from adipose tissue to the liver and induces the accumulation of fat in the liver, resulting in overproduction of VLDL1 particles and leading to the characteristic dyslipidaemia associated with type 2 diabetes.