Journal ArticleDOI
Correlation of phthalate exposures with semen quality
N. Pant,Manju Shukla,Devendra Kumar Patel,Y. R. Shukla,Neeraj Mathur,Yogendra Kumar Gupta,Daya K. Saxena +6 more
TLDR
It is suggestive that phthalates might be one among the contributing factors associated with the deterioration in semen quality and these adverse effects might be ROS, LPO and mitochondrial dysfunction mediated.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2008-08-15. It has received 224 citations till now. The article focuses on the topics: Phthalate & Semen quality.read more
Citations
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Journal ArticleDOI
Effect of oxidative stress on male reproduction.
TL;DR: This review highlights the mechanisms of ROS production, the physiological and pathophysiological roles of ROS in relation to the male reproductive system, and recent advances in diagnostic methods; it also explores the benefits of using antioxidants in a clinical setting.
Journal ArticleDOI
Reproductive and developmental effects of phthalate diesters in females.
TL;DR: There is sufficient evidence to suggest that phthalates are reproductive toxicants, however, it is noted that the concentrations needed to induce adverse health effects are high compared to the concentrations measured in contemporary human biomonitoring studies.
Journal ArticleDOI
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure
TL;DR: Levels of DEHP in food and bottled water were below current tolerable daily intake (TDI) values, however, the understanding of the risks ofDEHP exposure is still evolving, and the precautionary principle would suggest its phaseout and replacement.
Journal ArticleDOI
Phthalate exposure and male reproductive outcomes: A systematic review of the human epidemiological evidence.
TL;DR: Overall, despite some inconsistencies across phthalates in the specific outcomes associated with exposure, these results support that phthalate exposure at levels seen in human populations may have male reproductive effects, particularly DEHP and DBP.
Journal ArticleDOI
Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies
Joanna Jurewicz,Wojciech Hanke +1 more
TL;DR: There are strong and rather consistent indications that phthalates increase the risk of allergy and asthma and have an adverse impact on children’s neurodevelopment reflected by quality of alertness among girls, decreased (less masculine) composite score in boys and attention deficit hyperactivity disorder.
References
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Journal ArticleDOI
Phthalates: Toxicology and exposure
TL;DR: This paper presents an overview on current risk assessments done by expert panels as well as on exposure assessment data, based on ambient and on current human biomonitoring results, that prove that the tolerable intake of children is exceeded to a considerable degree.
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Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic
Donald P. Evenson,Lorna K. Jost,D Marshall,M J Zinaman,E D Clegg,K Purvis,P. De Angelis,O P Claussen +7 more
TL;DR: Based on logistic regression, spermatozoa with denatured DNA (cells outside the main population, COMP alpha t) were the best predictor for whether a couple would not achieve pregnancy.
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Human exposure to phthalates via consumer products
TL;DR: Oven baking of polymer clays may cause short-term, high-level inhalation exposures to higher molecular weight phthalates and cosmetics, personal care products, pharmaceuticals, nutritional supplements, herbal remedies and insecticides, may result in significant but poorly quantified human exposures.
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Phthalate exposure and human semen parameters.
Susan M. Duty,Manori J. Silva,Dana B. Barr,John W. Brock,Louise Ryan,Zuying Chen,Robert F. Herrick,David C. Christiani,Russ Hauser +8 more
TL;DR: There were dose-response relations for mono-butylphthalate and monobenzyl phthalate with one or more semen parameters, and suggestive evidence for monomethyl phhalate with sperm morphology, and the lack of a relation for other phthalates may indicate a difference in spermatotoxicity amongphthalates.
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Altered Semen Quality in Relation to Urinary Concentrations of Phthalate Monoester and Oxidative Metabolites
TL;DR: The present study confirms previous results on the relationship of altered semen quality with exposure to MBP at general population levels and includes measurements of di(2-ethylhexyl) phthalate (DEHP) oxidative metabolites.