Journal ArticleDOI
Crimean–Congo hemorrhagic fever
TLDR
The history, epidemiology, ecology, clinical features, pathogenesis, diagnosis, and treatment of CCHF are reviewed, and issues related to its possible use as a bioterrorism agent are discussed.About:
This article is published in Antiviral Research.The article was published on 2004-12-01. It has received 931 citations till now. The article focuses on the topics: Crimean Congo hemorrhagic fever virus & Crimean–Congo hemorrhagic fever.read more
Citations
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Crimean-Congo haemorrhagic fever
TL;DR: Crimean-Congo haemorrhagic fever (CCHF) is an often fatal viral infection described in about 30 countries, and it has the most extensive geographic distribution of the medically important tickborne viral diseases, closely approximating the known global distribution of Hyalomma spp ticks.
Journal ArticleDOI
Ticks feeding on humans: a review of records on human-biting Ixodoidea with special reference to pathogen transmission.
TL;DR: Despite the fact that most people who are bitten destroy the offending tick in disgust, it is recommended that they preserve specimens in ethanol for taxonomic identification and detection of pathogens by molecular methods.
Journal ArticleDOI
Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.
Natalia Frias-Staheli,Nadia V. Giannakopoulos,Marjolein Kikkert,Shannon L. Taylor,Anne Bridgen,Jason Paragas,Juergen A. Richt,Raymond R. R. Rowland,Connie S. Schmaljohn,Deborah J. Lenschow,Eric J. Snijder,Adolfo García-Sastre,Herbert W. Virgin +12 more
TL;DR: The deconjugating activity of viral OTU proteases represents a unique viral strategy to inhibit Ub- and ISG15-dependent antiviral pathways.
Journal ArticleDOI
The emergence of arthropod-borne viral diseases: A global prospective on dengue, chikungunya and zika fevers.
TL;DR: The focus of this review will be on dengue, zika and chikungunya viruses, particularly because these viruses are currently causing a negative impact on public health and economic damage around the world.
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Characteristics of Patients with Crimean-Congo Hemorrhagic Fever in a Recent Outbreak in Turkey and Impact of Oral Ribavirin Therapy
Onder Ergonul,Aysel Kocagul Celikbas,Başak Dokuzoğuz,Sebnem Eren,Nurcan Baykam,Harika Esener +5 more
TL;DR: The epidemiological, clinical, and laboratory findings and the role of ribavirin therapy for 35 patients who received a diagnosis of Crimean-Congo hemorrhagic fever are described and used to treat patients with CCHF.
References
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Journal ArticleDOI
The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa.
TL;DR: It was only in 1967, when Soviet workers first used the generally accepted newborn white mouse inoculation technique for CCHF virus isolation and study, that the etiologic agent could be characterized antigenically, physiochemically, and morphologically.
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Hemorrhagic Fever Viruses as Biological Weapons: Medical and Public Health Management
Luciana Borio,Thomas V. Inglesby,Clarence J. Peters,Alan L. Schmaljohn,James M. Hughes,Peter B. Jahrling,Thomas G. Ksiazek,Karl M. Johnson,Andrea Meyerhoff,Tara O'Toole,Michael S. Ascher,John G. Bartlett,Joel G. Breman,Edward M. Eitzen,Margaret Hamburg,Jerry Hauer,Donald A. Henderson,Richard T. Johnson,Gigi Kwik,Marci Layton,Scott R. Lillibridge,Gary J. Nabel,Michael T. Osterholm,Trish M. Perl,Philip K. Russell,Kevin Tonat +25 more
TL;DR: Weapons disseminating a number of HFVs could cause an outbreak of an undifferentiated febrile illness 2 to 21 days later, associated with clinical manifestations that could include rash, hemorrhagic diathesis, and shock.
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Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR.
Christian Drosten,Stephan Göttig,Stefan Schilling,Marcel Asper,Marcus Panning,Herbert Schmitz,Stephan Günther +6 more
TL;DR: The suitability of the assays was exemplified by detection and quantification of viral RNA in serum samples of VHF patients, and all assays were thoroughly optimized and validated in terms of analytical sensitivity by using in vitro-transcribed RNA.
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Rapid Diagnosis of Ebola Hemorrhagic Fever by Reverse Transcription-PCR in an Outbreak Setting and Assessment of Patient Viral Load as a Predictor of Outcome
Jonathan S. Towner,Pierre E. Rollin,Daniel G. Bausch,Anthony Sanchez,Sharon M. Crary,Martin J. Vincent,William F. Lee,Christina F. Spiropoulou,Thomas G. Ksiazek,Mathew Lukwiya,Felix Kaducu,Robert Downing,Stuart T. Nichol +12 more
TL;DR: This Sudan ebolavirus strain was not derived from either the earlier Boniface (1976) or Maleo (1979) strain, but it shares a common ancestor with both.