Crystal Structure of Soluble Domain of Malaria Sporozoite Protein UIS3 in Complex with Lipid
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TLDR
The crystal structure of Plasmodium falciparum UIS3 soluble domain in complex with the lipid phosphatidylethanolamine (PE) provides a new target for abrogating parasite development within liver cells before typical symptoms of malaria can manifest.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-08-29 and is currently open access. It has received 38 citations till now. The article focuses on the topics: Plasmodium falciparum & Fatty acid-binding protein.read more
Citations
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Journal ArticleDOI
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development
Ashley M. Vaughan,Matthew T. O'Neill,Alice S. Tarun,Nelly Camargo,Thuan Phuong,Ahmed S. I. Aly,Alan F. Cowman,Stefan H. I. Kappe,Stefan H. I. Kappe +8 more
TL;DR: It is shown in a rodent malaria model that FAS II enzymes localize to the sporozoite and liver stage apicoplast and deletion of FabI in the human malaria parasite Plasmodium falciparum did not show a reduction in asexual blood stage replication in vitro, indicating that malaria parasites depend on the intrinsic FASII pathway only at one specific life cycle transition point, from liver to blood.
Journal ArticleDOI
Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host
TL;DR: What is known about the molecular and cellular basis of the developmental progression of parasites and their interactions with host tissues in the mosquito and during the early phase of mammalian infection is discussed.
Journal ArticleDOI
Malaria parasite pre-erythrocytic stage infection: gliding and hiding.
TL;DR: How the infectious sporozoite makes its way to the liver and subsequently develops within hepatocytes is reviewed and the factors, both parasite and host, involved in the interactions that occur during this "silent" phase of infection are discussed.
Journal ArticleDOI
Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.
Srinivasan Ramakrishnan,Melissa D. Docampo,James I. MacRae,François M. Pujol,Carrie F. Brooks,Giel G. van Dooren,J. Kalervo Hiltunen,Alexander J. Kastaniotis,Malcolm J. McConville,Boris Striepen +9 more
TL;DR: The apicoplast is a significant source of fatty acids, and its products are further modified in the parasite endoplasmic reticulum, and this elongase pathway appears to have a unique role in generating very long unsaturated fatty acids that cannot be salvaged from the host.
Journal ArticleDOI
Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis
V. Jain,Manickam Yogavel,Yoshiteru Oshima,Haruhisa Kikuchi,Bastien Touquet,Bastien Touquet,Mohamed-Ali Hakimi,Mohamed-Ali Hakimi,Amit Sharma +8 more
TL;DR: It is shown that FF-based derivatives arrest parasite growth by direct interaction with and inhibition of the protein translation enzyme prolyl-tRNA synthetase (PRS), suggesting wider HF efficacy against parasitic PRSs.
References
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Book ChapterDOI
Processing of X-ray diffraction data collected in oscillation mode
Zbyszek Otwinowski,Wladek Minor +1 more
TL;DR: The methods presented in the chapter have been applied to solve a large variety of problems, from inorganic molecules with 5 A unit cell to rotavirus of 700 A diameters crystallized in 700 × 1000 × 1400 A cell.
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Coot: model-building tools for molecular graphics.
Paul Emsley,Kevin Cowtan +1 more
TL;DR: CCP4mg is a project that aims to provide a general-purpose tool for structural biologists, providing tools for X-ray structure solution, structure comparison and analysis, and publication-quality graphics.
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Refinement of macromolecular structures by the maximum-likelihood method.
TL;DR: The likelihood function for macromolecular structures is extended to include prior phase information and experimental standard uncertainties and the results derived are consistently better than those obtained from least-squares refinement.
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PHENIX: building new software for automated crystallographic structure determination
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TL;DR: A novel software package called PHENIX (Python-based Hierarchical ENvironment for Integrated Xtallography) is developed, which will provide the necessary algorithms to proceed from reduced intensity data to a refined molecular model and to facilitate structure solution for both the novice and expert crystallographer.
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The global distribution of clinical episodes of Plasmodium falciparum malaria
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