Cytosolic modulators of activities of microsomal enzyme of cholesterol biosynthesis. Role of a cytosolic protein with properties similar to Z-protein (fatty acid-binding protein).
J T Billheimer,J L Gaylor +1 more
TLDR
Rat liver cytosol contains proteins and smaller molecules that affect activities of the microsomal enzymes of cholesterol biosynthesis, and one protein appears to be very similar to Z-protein that has been shown by others to be identical with hepatic fatty-acid binding protein.About:
This article is published in Journal of Biological Chemistry.The article was published on 1980-09-10 and is currently open access. It has received 84 citations till now. The article focuses on the topics: Microsomal triglyceride transfer protein & Binding protein.read more
Citations
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Journal ArticleDOI
Structural and functional features of different types of cytoplasmic fatty acid-binding proteins
TL;DR: Article de synthese sur les donnees recentes de caracteristiques structurales et physicochimiques de divers types of proteines de liaison aux acides gras, avec la signification physiologique de ces diversites.
Book ChapterDOI
The cellular fatty acid binding proteins: aspects of structure, regulation, and function.
TL;DR: This chapter provides a comprehensive overview of the current state of knowledge of the research with particular emphasis on evolving concepts of fatty acid binding proteins (FABP) structure, regulation, and function.
Journal ArticleDOI
Fatty acid binding protein. Isolation from rat liver, characterization, and immunochemical quantification.
R K Ockner,J A Manning,J P Kane +2 more
TL;DR: The abundance of FABP, its importance in the cytosolic binding of endogenous as well as exogenous fatty acids, and its demonstrated correlation with rates of hepatocyte fatty acid utilization provide additional evidence for its relationship to the cellular metabolism of long chain fatty acids.
Journal ArticleDOI
The nucleotide sequence of rat liver fatty acid binding protein mRNA.
TL;DR: Evidence is presented which suggests that this protein is targeted to the cytoplasm, and no cleavable signal peptide sequence or internal signal sequence equivalent was detectable in a co-translational cleavage assay.
Journal ArticleDOI
Regulation of the biosynthesis of two distinct fatty acid-binding proteins in rat liver and intestine. Influences of sex difference and of clofibrate.
Nathan M. Bass,Joan A. Manning,Robert K. Ockner,Jeffrey I. Gordon,S Seetharam,David H. Alpers +5 more
TL;DR: The results indicate that the influence of sex difference and the effect of clofibrate on hepatic fatty acid metabolism are both associated with changes in hFABP synthesis mediated pretranslationally.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis
Klaus Weber,Mary Osborn +1 more
TL;DR: The results show that the polyacrylamide gel electrophoresis method can be used with great confidence to determine the molecular weights of polypeptide chains for a wide variety of proteins.
Journal ArticleDOI
Disc electrophoresis – ii method and application to human serum proteins*
TL;DR: The technique of disc electrophoresis has been presented, including a discussion of the technical variables with special reference to the separation of protein fractions of normal human serum.
Journal ArticleDOI
Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide Gels
TL;DR: DISK electrophoresis on small columns of polyacrylamide gels, a new method for the separation of serum proteins, has been developed by Ornstein and Davis1,2.
Related Papers (5)
Fatty acid binding protein. Isolation from rat liver, characterization, and immunochemical quantification.
R K Ockner,J A Manning,J P Kane +2 more